Description

D-Glucose-3,4-13C2 is a stable isotope-labeled analog of D-glucose, specifically enriched with carbon-13 at the 3 and 4 positions. This precise labeling is critical for advanced metabolic research, enabling scientists to trace glucose utilization and metabolic flux with high specificity and accuracy. It is an essential tool for researchers and analytical laboratories in the fields of metabolomics, pharmaceutical development, and clinical diagnostics, where understanding biochemical pathways is paramount.

Application

• Metabolic Flux Analysis (MFA): Used as a tracer to quantify intracellular metabolic pathway rates in cell cultures, tissues, and whole organisms.
• Drug Metabolism and Pharmacokinetics (DMPK): Serves as an internal standard in LC-MS and GC-MS for the accurate quantification of glucose and its metabolites in biological samples.
• Clinical Research: Enables detailed studies of glucose metabolism disorders, such as diabetes and cancer metabolism.
• Biochemical Pathway Elucidation: Aids in mapping and validating central carbon metabolism pathways like glycolysis and the pentose phosphate pathway.
• Stable Isotope Labeling in Cell Culture (SILAC) and related proteomics: Can be incorporated into growth media for the production of isotopically labeled biomolecules.
• NMR Spectroscopy: Provides a distinct signal for structural and dynamic studies of carbohydrate metabolism.

Basic Information

Product Name	D-Glucose-3,4-13C2
CAS No.	67759-25-5
Molecular Formula	C6H12O6 (with 13C at positions 3 & 4)
Molecular Weight	182.15 g/mol (approx., based on isotopic enrichment)
Synonyms	D-(+)-Glucose-3,4-13C2; (3,4-13C2)-D-Glucose; D-Glucose (3,4-13C2); 13C2-Labeled D-Glucose; Dextrose-3,4-13C2; Blood Sugar-3,4-13C2; Grape Sugar-3,4-13C2; Isotopic Tracer D-Glucose
EINECS	Contact for details

Quality Control

Every batch of D-Glucose-3,4-13C2 is manufactured and tested under strict quality systems to ensure the highest isotopic and chemical purity. Our standard quality commitment includes verification of isotopic enrichment (Atom % 13C), chemical purity, and optical rotation. A comprehensive Certificate of Analysis (COA) detailing NMR, MS, and HPLC results is provided with each shipment to guarantee consistency and reliability for your sensitive research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0% (chemical purity)
Isotopic Enrichment (MS)	≥ 99 atom % 13C at positions 3 & 4
Specific Optical Rotation	+52.5° to +53.0° (c=10, H2O)
Water Content (KF)	≤ 1.0 %
Residue on Ignition	≤ 0.1 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.