Description

Methylcholanthrene-9,10-Dihydrodiol is a key dihydrodiol metabolite of the potent polycyclic aromatic hydrocarbon carcinogen, 3-Methylcholanthrene. This compound is of significant value in biochemical and toxicological research, serving as a critical intermediate for studying metabolic activation pathways and DNA adduct formation. It is primarily utilized by researchers and analytical laboratories in the fields of oncology, environmental toxicology, and pharmaceutical development for mechanistic studies and as a reference standard.

Application

• Biochemical Research: Used as a standard and intermediate in studies investigating the metabolic activation pathways of polycyclic aromatic hydrocarbons (PAHs).
• Toxicology Studies: Essential for in vitro and in vivo research on carcinogenesis, specifically for understanding the role of diol-epoxide metabolites in DNA binding and mutagenicity.
• Analytical Reference Standard: Serves as a high-purity calibrant in chromatographic analyses (HPLC, GC-MS) for quantifying PAH metabolites in complex biological and environmental samples.
• Pharmaceutical Development: Employed in early-stage research for screening compounds that may inhibit specific cytochrome P450 enzymes involved in procarcinogen activation.
• Environmental Science: Applied in assays designed to assess the metabolic fate and potency of methylcholanthrene and related pollutants.

Basic Information

Product Name	Methylcholanthrene-9,10-Dihydrodiol
CAS No.	67481-32-7
Molecular Formula	C21H16O2
Molecular Weight	300.35 g/mol
Synonyms	9,10-Dihydroxy-9,10-dihydro-3-methylcholanthrene; 3-Methylcholanthrene 9,10-dihydrodiol; trans-9,10-Dihydroxy-9,10-dihydro-3-methylcholanthrene; 3-MC 9,10-diol; 3-Methylcholanthrene dihydrodiol; (±)-9,10-Dihydroxy-9,10-dihydro-3-methylcholanthrene; 9,10-Dihydro-9,10-dihydroxy-3-methylcholanthrene
EINECS	Contact for details

Quality Control

Our Methylcholanthrene-9,10-Dihydrodiol is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including purity assay by HPLC and structural confirmation by spectroscopic methods. A detailed Certificate of Analysis (COA) providing full specification data is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is light-sensitive (store away from light). For long-term storage, consider storage under inert atmosphere at lower temperatures (-20°C).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Melting Point	Contact for details
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.