Description

Malononitrile, [1-14C] is a carbon-14 radiolabeled analog of malononitrile, a versatile building block in organic synthesis. This isotopically labeled compound is essential for conducting detailed metabolic and pharmacokinetic studies, providing critical data on the fate of molecules within biological systems. It is primarily used by researchers and scientists in the pharmaceutical, agrochemical, and life science industries for drug discovery, development, and environmental tracing applications.

Application

• Tracer Studies in Pharmaceutical R&D: Used to investigate the absorption, distribution, metabolism, and excretion (ADME) of new chemical entities and drug candidates.
• Metabolic Pathway Analysis: Enables the elucidation of biochemical pathways in plants, animals, and microorganisms.
• Agrochemical Research: Applied in studies to understand the environmental fate, degradation, and residue analysis of pesticides and herbicides.
• Organic Synthesis Intermediate: Serves as a labeled precursor for synthesizing more complex 14C-labeled heterocycles, pharmaceuticals, and fine chemicals.
• Mechanistic Studies: Facilitates research into reaction mechanisms in organic chemistry by tracking the specific carbon atom.
• Radiochemical Reference Standard: Used as a standard in analytical methods like HPLC-radiochemical detection for quantification.

Basic Information

Product Name	Malononitrile, [1-14C]
CAS No.	67120-87-0
Molecular Formula	C314CN2
Molecular Weight	~68.04 g/mol (exact mass depends on specific activity)
Synonyms	1-Cyano-1-[14C]cyanoethane; [1-14C]Malononitrile; Propanedinitrile, 1-14C; Dicyanomethane-1-14C; Malonodinitrile-1-14C; Carbon-14 Labeled Malononitrile; Radiolabeled Malononitrile
EINECS	Contact for details

Quality Control

Every batch of Malononitrile, [1-14C] is manufactured and analyzed under strict quality control protocols to ensure high chemical and radiochemical purity, specific activity, and stability. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing parameters such as radiochemical purity (by HPLC or TLC), chemical purity, specific activity, and solvent composition. Our quality system is designed to meet the stringent requirements of research and regulatory applications.

Storage

Preserve in a tightly closed container, protected from light. Store at the recommended temperature (typically 2-8°C or as specified on the label) in a designated, secure area for radioactive materials. This compound is hygroscopic (moisture-sensitive); ensure containers are sealed properly after use to prevent degradation. All handling and storage must comply with local and international regulations for radioactive substances.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Chemical Purity (HPLC)	≥ 95%
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	Customizable (mCi/mmol range)
Solvent	Specified on COA (e.g., Acetonitrile, Toluene)
Concentration	Specified on COA
Identification (IR / NMR)	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.