Description

Pumiliotoxin A CAS NO 67054-00-6 is a potent alkaloid neurotoxin originally isolated from the skin of poison dart frogs (*Dendrobatidae* family). This compound is of significant interest in neuroscience and pharmacological research due to its highly specific action on voltage-gated sodium channels. It serves as a critical research tool for studying ion channel function, neuronal signaling pathways, and the development of novel therapeutic agents. Key industries that utilize this specialized biochemical include academic and pharmaceutical R&D, toxicology, and the development of biochemical probes.

Application

• Neuroscience Research: As a selective modulator of sodium channels for studying neuronal excitability and signal transduction.
• Pharmacological Probe Development: Used in the design and screening of new drugs targeting ion channel-related disorders.
• Toxicology Studies: Serves as a reference standard in the investigation of natural neurotoxins and their mechanisms of action.
• Biochemical Assays: Employed in in vitro assays to characterize channel kinetics and inhibitor potency.
• Academic Reference Material: Used in university and institutional labs for advanced chemical biology and natural product chemistry courses.

Basic Information

Product Name	Pumiliotoxin A
CAS No.	67054-00-6
Molecular Formula	C19H31NO2
Molecular Weight	305.46 g/mol
Synonyms	Pumiliotoxin 251D; PTX 251D; (8R,8aS)-8-Methyl-6-[(2R)-2-methyl-1-pyrrolidinyl]-5,6,7,8,8a,9-hexahydroindolizine-3,8-diol; Allopumiliotoxin 267A; 8-Methyl-6-(2-methyl-1-pyrrolidinyl)-5,6,7,8,8a,9-hexahydroindolizine-3,8-diol
EINECS	Contact for details

Quality Control

Our Pumiliotoxin A is produced and handled under strict quality protocols to ensure batch-to-batch consistency and integrity for sensitive research applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and MS to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, analytical methods, and results is provided with every shipment to support your compliance and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. The container should be kept in a cool, dry, and well-ventilated area. Allow the product to reach room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.