Description

(R)-Hexahydro-1H-Azepine-2-Carboxylic Acid CAS NO 66865-36-9 is a high-purity, non-proteinogenic chiral amino acid derivative featuring a seven-membered azepine ring. This compound serves as a critical advanced pharmaceutical intermediate and a versatile chiral building block for the synthesis of complex bioactive molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing new therapeutic agents and fine chemicals.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and production of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disorder therapeutics.
• Peptidomimetic Chemistry: Used to introduce conformational constraints and modify peptide backbones in the design of peptide-based drugs and protease inhibitors.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in catalytic asymmetric reactions to construct stereogenic centers with high enantiomeric purity.
• Agrochemical Research: Building block for developing new chiral herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Development: Useful precursor for synthesizing novel chiral ligands and organocatalysts used in homogeneous catalysis.
• Academic & Industrial R&D: Serves as a standard and starting material in medicinal chemistry and organic synthesis research programs.

Basic Information

Item	Details
Product Name	(R)-Hexahydro-1H-Azepine-2-Carboxylic Acid
CAS No.	66865-36-9
Molecular Formula	C7H13NO2
Molecular Weight	143.18 g/mol
Synonyms	(R)-Perhydroazepine-2-carboxylic acid; (R)-2-Azepanecarboxylic acid; (R)-Hexahydro-1H-azepine-2-carboxylic acid; (R)-Homopipecolic acid; (2R)-Hexahydro-1H-azepine-2-carboxylic acid; (R)-Aminoazepane-2-carboxylic acid; (R)-2-Carboxyazepane; (R)-Cyclohexane-1,2-diamine-2-carboxylic acid derivative
EINECS	Contact for details

Quality Control

Our (R)-Hexahydro-1H-Azepine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.