Description

Acyclovir, Monophosphate CAS NO 66341-16-0 is the monophosphate ester derivative of the well-known antiviral nucleoside analogue acyclovir. This phosphorylated form is a critical intermediate in the synthesis of more complex antiviral prodrugs and nucleotide analogues, enhancing bioavailability and therapeutic efficacy. It is essential for pharmaceutical R&D and manufacturing sectors focused on developing advanced antiviral therapies, particularly against herpesviruses.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the production of nucleotide-based antiviral drugs and prodrugs.
• Antiviral Drug Development: Used in research and development of next-generation antiviral agents targeting herpes simplex virus (HSV), varicella-zoster virus (VZV), and Epstein-Barr virus (EBV).
• Prodrug Synthesis: Serves as a building block for creating more lipophilic or bio-activatable prodrug forms of acyclovir to improve oral absorption and cellular uptake.
• Biochemical Research: Employed in enzymatic studies and as a substrate to investigate viral kinase and polymerase activity.
• Reference Standard: Utilized as a high-purity analytical standard in quality control laboratories for method development and validation.
• Active Pharmaceutical Ingredient (API) Manufacturing: An intermediate in the multi-step synthesis of final active pharmaceutical ingredients for antiviral formulations.

Basic Information

Item	Details
Product Name	Acyclovir, Monophosphate
CAS No.	66341-16-0
Molecular Formula	C8H12N5O6P
Molecular Weight	305.18 g/mol
Synonyms	9-[(2-Hydroxyethoxy)methyl]guanine monophosphate; Acyclovir 5'-Monophosphate; Acyclovir Monophosphate; Acyclovir phosphate; ACV-MP; NSC 401005; 2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one 5'-(dihydrogen phosphate)
EINECS	Contact for details

Quality Control

Our Acyclovir Monophosphate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and stringent controls for residual solvents and impurities. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with cGMP and relevant pharmaceutical guidelines for intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.