Description

Ibopamine is a synthetic catecholamine prodrug that undergoes enzymatic conversion to dopamine, exhibiting selective dopaminergic and adrenergic activity. It is valued in pharmaceutical research for its hemodynamic modulation properties and utility as a reference standard in analytical method development. Researchers and contract development and manufacturing organizations (CDMOs) engaged in cardiovascular drug discovery, pharmacokinetic studies, and impurity profiling rely on high-purity Ibopamine CAS NO 66195-31-1 for reproducible, regulatory-compliant results.

Application

• Pharmaceutical reference standard for HPLC and LC-MS calibration in dopamine agonist analysis
• Key intermediate in the synthesis of dopaminergic prodrugs and metabolite analogues
• Research tool in preclinical cardiovascular pharmacology studies assessing renal perfusion and cardiac output
• Impurity reference material for stability-indicating assay validation per ICH Q5 and Q7 guidelines
• Quality control benchmark for generic dopamine receptor modulator manufacturers
• Substance used in forced degradation studies to characterize oxidative and photolytic degradation pathways

Basic Information

Product Name	Ibopamine
CAS No.	66195-31-1
Molecular Formula	C18H25NO4
Molecular Weight	319.40 g/mol
Synonyms	Ibopamine; 3-[(2-Aminoethyl)oxy]-4-hydroxy-N-(1-methyl-2-phenylethyl)benzamide; NSC 224115; U-11116; Dopastat; 3-(2-Aminoethoxy)-4-hydroxy-N-(α-methylbenzyl)benzamide; N-(1-Methyl-2-phenylethyl)-3-[(2-aminoethyl)oxy]-4-hydroxybenzamide; Ibopamine hydrochloride (common salt form)
EINECS	266-174-3

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches are tested per ICH Q2(R2) guidelines for identification, assay, and impurity profiling. Testing includes HPLC purity determination, melting point verification, residual solvent analysis (GC), and heavy metals screening (ICP-MS). Complies with applicable sections of USP General Chapters 〈466〉 Heavy Metals and 〈621〉 Chromatography.

Storage

Preserve in a tightly closed container, protected from light. Store at 15–25°C in a dry, well-ventilated area. Avoid exposure to moisture and elevated temperatures. Due to its light-sensitive nature, minimize handling under direct or UV light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.5% – 101.0%
Related Substances (HPLC)	≤ 1.5% total impurities
Residual Solvents (GC)	Meets ICH Q3C limits
Water (Karl Fischer)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.