Description

Fluorescein Colchicine is a fluorescently labeled derivative of the potent alkaloid colchicine, designed for advanced research and diagnostic applications. This compound is crucial for scientists requiring a high-affinity, traceable probe to study tubulin dynamics, cellular transport mechanisms, and intracellular processes. It is primarily utilized by researchers in pharmaceutical development, cell biology, and molecular diagnostics who need precise visualization and quantification of colchicine-binding sites.

Application

• Biochemical Research: As a fluorescent probe for studying microtubule assembly and disassembly kinetics in vitro.
• Cellular Imaging: For visualizing and tracking tubulin binding and intracellular localization in live or fixed cells using fluorescence microscopy.
• Drug Discovery Assays: Used in high-throughput screening (HTS) and binding assays to identify and evaluate novel compounds targeting the colchicine site on tubulin.
• Diagnostic Development: Potential use in developing fluorescence-based diagnostic tests for conditions related to cytoskeletal dysfunction.
• Pharmacology Studies: Investigating the pharmacokinetics, biodistribution, and mechanism of action of colchicine derivatives.

Basic Information

Product Name	Fluorescein Colchicine
CAS No.	66091-34-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Colchicine-fluorescein conjugate; Fluorescein-labeled Colchicine; FITC-Colchicine; Colchicine, fluorescein derivative; N-(Fluorescein-5-thiocarbamoyl)colchicine; Tubulin binding fluorescent probe; Colchicine fluorescent tracer
EINECS	Contact for details

Quality Control

Our Fluorescein Colchicine is produced under stringent quality management systems to ensure batch-to-batch consistency and high performance in sensitive applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications and test results are available upon request to support your research and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and desiccated to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	Orange to red solid
Identification (HPLC/UV)	Conforms
Purity (HPLC)	≥ 95%
Fluorescence Properties	Conforms to reference
Solubility	Soluble in DMSO, DMF
Moisture Content	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.