Description

Dl-Leucine-2-13C CAS NO 65792-32-7 is a stable isotope-labeled analog of the essential branched-chain amino acid leucine, where the carbon atom at the 2-position is enriched with the 13C isotope. This compound is a critical tool in metabolic research, enabling precise tracking and quantification of leucine incorporation and turnover in biological systems. It is primarily utilized by researchers and manufacturers in the pharmaceutical, nutritional science, and biomedical diagnostics sectors for advanced tracer studies, metabolic flux analysis, and the development of internal standards for mass spectrometry.

Application

• Metabolic Tracer Studies: Used in in vivo and in vitro research to investigate protein synthesis, degradation, and amino acid metabolism pathways.
• Mass Spectrometry Internal Standard: Serves as a critical isotopic internal standard for the accurate quantification of natural leucine in complex biological matrices via LC-MS/MS and GC-MS.
• Nutritional & Clinical Research: Employed in studies examining muscle metabolism, liver function, and metabolic disorders to understand leucine's role in health and disease.
• Pharmaceutical Development: Utilized in drug metabolism and pharmacokinetics (DMPK) studies to trace the metabolic fate of drug candidates containing or affecting leucine pathways.
• Biochemical Reagent: Acts as a labeled substrate in enzymatic assays and for the production of other 13C-labeled biochemical compounds.

Basic Information

Product Name	Dl-Leucine-2-13C
CAS No.	65792-32-7
Molecular Formula	C6H13NO2 (with 13C at position 2)
Molecular Weight	132.16 g/mol (13C labeled)
Synonyms	(±)-2-Amino-4-methylpentanoic acid-2-13C; DL-Leucine-2-13C; 13C Labeled DL-Leucine; Leucine-2-13C (racemic); 2-Amino-4-methylvaleric acid-2-13C; 13C1-DL-Leucine; (RS)-2-Amino-4-methylpentanoic acid-2-13C; Isotopic leucine standard
EINECS	Contact for details

Quality Control

Our Dl-Leucine-2-13C is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high chemical purity and isotopic enrichment. Certificates of Analysis (COA) are provided, detailing specifications for isotopic purity (atom % 13C), chemical purity (HPLC), and identification (IR, NMR). We support research and industrial applications requiring reliable and consistent isotopic label integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (atom % 13C)	≥ 99%
Chemical Purity (Titration)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.