Description

4-Iodoantipyrene-n-Methyl-14C is a carbon-14 radiolabeled derivative of the antipyretic agent antipyrine, specifically designed for advanced metabolic and pharmacokinetic research. This compound is crucial for high-sensitivity tracer studies, enabling precise tracking of drug disposition and biotransformation pathways in biological systems. It is an essential tool for pharmaceutical R&D scientists, toxicologists, and analytical chemists working in drug development, ADME (Absorption, Distribution, Metabolism, and Excretion) studies, and environmental fate analysis.

Application

• Pharmaceutical ADME Studies: Used as a radiolabeled tracer to investigate the metabolic fate, bioavailability, and excretion profiles of drug candidates and related chemical entities.
• Biomedical Research: Employed in autoradiography and imaging studies to visualize and quantify the distribution of compounds in tissues and organs.
• Metabolic Pathway Elucidation: Aids in identifying and characterizing novel metabolites and understanding enzymatic transformation mechanisms.
• Environmental Toxicology: Applied in studies to trace the degradation, persistence, and bioaccumulation of chemical compounds in ecological systems.
• Analytical Method Development: Serves as a critical internal standard or reference material in developing and validating sensitive LC-MS/MS and radio-HPLC methods.
• Chemical Synthesis Intermediate: Acts as a building block for synthesizing other radiolabeled compounds for research purposes.

Basic Information

Product Name	4-Iodoantipyrene-n-Methyl-14C
CAS No.	65550-46-1
Molecular Formula	C12H13IN2O * (14C labeled)
Molecular Weight	~316.15 g/mol (unlabeled)
Synonyms	1-Phenyl-2,3-dimethyl-4-iodo-5-pyrazolone-3-N-methyl-14C; 4-Iodo-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one-3-N-methyl-14C; [3-14C]-4-Iodoantipyrine; 14C-Labeled 4-Iodoantipyrine; Radiolabeled 4-Iodoantipyrine; Carbon-14 4-Iodoantipyrine
EINECS	Contact for details

Quality Control

Every batch of 4-Iodoantipyrene-n-Methyl-14C is manufactured and analyzed under strict quality systems. We guarantee high chemical and radiochemical purity, with specifications typically meeting or exceeding the requirements for research-grade radiolabeled compounds. Comprehensive testing includes assay by HPLC, radiochemical purity determination, and specific activity verification. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at recommended temperatures (typically 2-8°C or as specified on the label) in a designated, secure area for radioactive materials. Follow all applicable local and international regulations for the storage, handling, and disposal of radioactive substances.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference
Assay (HPLC)	≥ 98% (chemical purity)
Radiochemical Purity	≥ 97%
Specific Activity	Customizable (mCi/mmol range)
Solubility	Soluble in common organic solvents (e.g., DMSO, ethanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.