Description

(R)-(+)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Bi-2-Naphthol CAS NO 65355-00-2 is a high-purity, chiral binaphthol derivative that serves as a critical ligand and building block in asymmetric synthesis. Its value lies in its ability to impart exceptional enantioselectivity in catalytic reactions, directly impacting the efficiency and cost-effectiveness of producing single-enantiomer compounds. This product is essential for research and development laboratories, as well as production facilities in the pharmaceutical, agrochemical, and fine chemical industries, where precise stereochemical control is paramount.

Application

• Asymmetric Catalysis: As a privileged chiral ligand for transition metal catalysts (e.g., Ru, Rh, Pd) in hydrogenation, coupling, and cycloaddition reactions.
• Pharmaceutical Intermediates: Key chiral auxiliary in the synthesis of active pharmaceutical ingredients (APIs) requiring high enantiomeric purity.
• Chiral Resolution: Used to prepare chiral stationary phases for HPLC or as a resolving agent for racemic mixtures.
• Material Science: Building block for chiral polymers, liquid crystals, and molecular recognition systems.
• Agrochemical Synthesis: Enantioselective production of herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: Fundamental reagent for developing new asymmetric methodologies and exploring novel catalytic systems.

Basic Information

Product Name	(R)-(+)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Bi-2-Naphthol
CAS No.	65355-00-2
Molecular Formula	C₂₀H₂₂O₂
Molecular Weight	294.39 g/mol
Synonyms	(R)-(+)-H8-BINOL; (R)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-binaphthyl-2,2'-diol; (R)-Octahydro-1,1'-bi-2-naphthol; (R)-H8BINOL; (R)-1,1'-Bi-2-naphthol, 5,5',6,6',7,7',8,8'-octahydro-, (R)-; (R)-Perhydro-1,1'-binaphthyl-2,2'-diol; (R)-(+)-Octahydrobinol; (R)-H8-BINOL
EINECS	Contact for details

Quality Control

Our (R)-(+)-H8-BINOL is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, to ensure it meets the high-purity standards required for sensitive asymmetric synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	168 - 172 °C
Specific Rotation [α]²⁰D	+35.0° to +38.0° (c=1 in THF)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.