Description

(-)-8-Phenylmenthol CAS NO 65253-04-5 is a high-purity, enantiomerically pure chiral auxiliary and ligand widely used in asymmetric synthesis. This compound is valued for its ability to induce high levels of stereoselectivity in a variety of organic transformations, making it a critical tool for research and development in fine chemical and pharmaceutical manufacturing. It is essential for chemists and process engineers working in advanced organic synthesis, particularly for the production of chiral active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• As a chiral auxiliary in asymmetric alkylation, acylation, and Diels-Alder reactions.
• As a ligand for transition metal catalysts in enantioselective hydrogenation and carbon-carbon bond-forming reactions.
• In the resolution of racemic mixtures and the synthesis of enantiomerically pure compounds.
• For research and development of novel synthetic methodologies in academic and industrial laboratories.
• In the production of key intermediates for pharmaceuticals, including cardiovascular and central nervous system (CNS) drugs.
• For the synthesis of chiral flavors, fragrances, and agrochemicals.
• As a standard reference material for analytical method development and quality control.

Basic Information

Item	Details
Product Name	(-)-8-Phenylmenthol
CAS No.	65253-04-5
Molecular Formula	C16H24O
Molecular Weight	232.36 g/mol
Synonyms	(-)-8-Phenylmenthol; (1R,2S,5R)-2-(1-Phenylethyl)-5-methylcyclohexanol; (1R,2S,5R)-5-Methyl-2-(1-phenylethyl)cyclohexanol; (1R,2S,5R)-2-(α-Methylbenzyl)-5-methylcyclohexanol; L-8-Phenylmenthol; (R)-8-Phenylmenthol; (-)-trans-2-(1-Phenylethyl)-5-methylcyclohexanol; Phenylmenthol
EINECS	Contact for details

Quality Control

Our (-)-8-Phenylmenthol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for asymmetric synthesis. Certificates of Analysis (COA) with detailed specifications are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.