Description

3,5-Di(125I)Iodo-L-Tyrosine is a radiolabeled derivative of the amino acid L-tyrosine, specifically iodinated with the iodine-125 radioisotope. This compound is critical for research and development in radiopharmaceuticals and molecular biology, serving as a precise tracer for metabolic and receptor-binding studies. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and diagnostic imaging developers focusing on thyroid function, protein metabolism, and targeted radiotherapy.

Application

• Radiopharmaceutical Precursor: Used in the synthesis and development of novel diagnostic and therapeutic agents, particularly for thyroid-related disorders.
• Metabolic Tracer Studies: Acts as a radiolabeled tracer in biomedical research to investigate tyrosine metabolism, protein synthesis, and turnover in biological systems.
• Receptor Binding Assays: Employed in competitive binding and autoradiography studies to characterize and quantify hormone receptors and transporters.
• Thyroid Function Research: Essential for in vitro and in vivo studies on iodine uptake, organification, and thyroid hormone synthesis pathways.
• Molecular Imaging Probe Development: Serves as a key intermediate for creating targeted imaging probes for SPECT (Single-Photon Emission Computed Tomography) applications.
• Biochemical Labeling: Used to radiolabel peptides, antibodies, or other biomolecules for tracking and distribution studies.

Basic Information

Product Name	3,5-Di(125I)Iodo-L-Tyrosine
CAS No.	65214-01-9
Molecular Formula	C9H8125I2NO3
Molecular Weight	~503.0 g/mol (for unlabeled form C9H9I2NO3)
Synonyms	3,5-Diiodo-L-tyrosine, I-125; L-3,5-Diiodotyrosine (125I-labeled); 3,5-Diiodo-L-tyrosine, iodine-125; DIT (125I); 3,5-Diiodotyrosine-125I; (2S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid (125I); Radioiodinated DIT
EINECS	Contact for details

Quality Control

Every batch of 3,5-Di(125I)Iodo-L-Tyrosine is manufactured and controlled under strict quality systems. We provide comprehensive analytical data to ensure product integrity, including verification of radiochemical purity, specific activity, and chemical identity. A Certificate of Analysis (COA) detailing radionuclidic purity, radiochemical purity, and analytical methods is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at the temperature recommended on the product label or accompanying documentation, typically between 2°C and 8°C. Due to its radioactive nature and sensitivity, this material must be handled and stored in accordance with all applicable radiation safety regulations. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Radiochemical Purity (HPLC)	≥ 95%
Specific Activity	Provided on COA
Radionuclidic Purity	≥ 99%
Chemical Purity (HPLC)	≥ 98%
Solubility	Soluble in aqueous alkaline solutions, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.