Description

2-Fluoro-4-Hydroxybenzoic Acid is a fluorinated aromatic carboxylic acid derivative that serves as a versatile and high-value synthetic intermediate. Its molecular structure, featuring both a carboxylic acid and a phenolic hydroxyl group, makes it a critical building block for introducing specific functionalities into target molecules. This compound is essential for research and development chemists and manufacturers in the pharmaceutical and agrochemical sectors, where it is used to create novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring a fluorinated benzoic acid scaffold.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and plant growth regulators, where the fluorine atom can improve metabolic stability and bioavailability.
• Liquid Crystal Materials: Serves as a building block for fluorinated mesogens used in display technologies due to its ability to modify polarity and intermolecular interactions.
• Polymer Chemistry: Employed as a monomer or modifier to introduce fluorine and aromatic acid groups into specialty polymers, enhancing thermal and chemical resistance.
• Organic Synthesis & Research: A valuable reagent for academic and industrial research in medicinal chemistry and material science for constructing complex fluorinated aromatic systems.
• Dye and Pigment Intermediate: Used in the synthesis of specialized dyes and pigments where fluorine substitution can alter color fastness and spectral properties.

Basic Information

Product Name	2-Fluoro-4-Hydroxybenzoic Acid
CAS No.	65145-13-3
Molecular Formula	C7H5FO3
Molecular Weight	156.11 g/mol
Synonyms	4-Hydroxy-2-fluorobenzoic Acid; 2-Fluoro-4-hydroxybenzoic acid; Benzoic acid, 2-fluoro-4-hydroxy-; 2-Fluoro-p-hydroxybenzoic acid; 4-Carboxy-3-fluorophenol; 2-Fluoro-4-carboxyphenol; 65145-13-3; 2-F-4-HBA
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-Hydroxybenzoic Acid is produced under a strict quality management system. Every batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting key parameters such as assay, related substances, and residual solvents. Our quality commitment ensures the material meets the stringent requirements for use in regulated synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong bases, and strong acids.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	208°C - 212°C
Loss on Drying	≤0.5%
Related Substances (HPLC)	Total impurities ≤2.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.