Description

Ethyl-4-(Difluoromethyl)Benzoate is a high-purity organic ester compound featuring a difluoromethyl substituent on the aromatic ring. This fluorinated building block is valued for its role in introducing the difluoromethyl group, a key motif in modern medicinal and agrochemical discovery that can modulate lipophilicity, metabolic stability, and biological activity. It is primarily sought by research chemists and process development scientists in the pharmaceutical and crop protection industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key fluorinated synthon for the research and development of new drug candidates, particularly in areas like kinase inhibitors and metabolic disease therapies.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the difluoromethyl group enhances efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic compounds used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Sonogashira) and ester transformations to create complex, fluorinated molecular architectures.
• Material Science Research: Utilized in developing novel polymers and coatings with specific surface properties and improved chemical resistance.

Basic Information

Product Name	Ethyl-4-(Difluoromethyl)Benzoate
CAS No.	64747-71-3
Molecular Formula	C10H10F2O2
Molecular Weight	200.18 g/mol
Synonyms	Ethyl p-(Difluoromethyl)benzoate; 4-(Difluoromethyl)benzoic Acid Ethyl Ester; Benzoic acid, 4-(difluoromethyl)-, ethyl ester; Ethyl 4-(Difluoromethyl)benzoate; p-(Difluoromethyl)benzoic Acid Ethyl Ester; Ethyl α,α-Difluoro-p-toluate
EINECS	Contact for details

Quality Control

Every batch of Ethyl-4-(Difluoromethyl)Benzoate is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by GC/HPLC is supplied with each shipment. Our quality commitment supports compliance in cGMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.