Description

2-[2-(Diphenylphosphino)Phenyl]-4,5-Dihydro-4,4-Dimethyloxazole CAS NO 64691-33-4 is a specialized organophosphorus ligand featuring a chiral oxazoline backbone, making it a critical component in asymmetric catalysis. Its primary value lies in its ability to coordinate with transition metals to form highly active and selective catalysts for a variety of stereoselective transformations. This compound is essential for research and production in the fine chemical and pharmaceutical industries, where precise control over molecular chirality is paramount for developing active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Asymmetric Hydrogenation: A key ligand for rhodium and ruthenium catalysts used in the enantioselective reduction of prochiral olefins, ketones, and imines.
• Cross-Coupling Reactions: Employed in palladium-catalyzed reactions such as Suzuki-Miyaura and Heck couplings to achieve high enantioselectivity.
• Pharmaceutical Intermediate Synthesis: Critical for the production of chiral intermediates in the manufacture of complex drug molecules.
• Agrochemical Research: Used in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Material Science: Facilitates the synthesis of chiral polymers and liquid crystals with specific optical properties.
• Academic & Industrial R&D: A valuable tool for chemists exploring new catalytic methodologies and reaction pathways.

Basic Information

Product Name	2-[2-(Diphenylphosphino)Phenyl]-4,5-Dihydro-4,4-Dimethyloxazole
CAS No.	64691-33-4
Molecular Formula	C23H22NOP
Molecular Weight	359.40 g/mol
Synonyms	(S)-2-[2-(Diphenylphosphino)phenyl]-4,5-dihydro-4,4-dimethyloxazole; (S)-4,4-Dimethyl-2-[2-(diphenylphosphino)phenyl]-2-oxazoline; PHOX Ligand; (S)-t-Bu-PHOX; Josiphos-type ligand analog; Chiral phosphinooxazoline ligand; P,N-Ligand
EINECS	Contact for details

Quality Control

Every batch of our 2-[2-(Diphenylphosphino)Phenyl]-4,5-Dihydro-4,4-Dimethyloxazole undergoes rigorous analytical testing to ensure high chemical purity and enantiomeric excess (ee) suitable for demanding catalytic applications. Our quality assurance protocols are designed to meet the stringent requirements of pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and identity is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity to oxidation, this product should be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended long-term storage temperature is 2-8°C. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.