Description

10,11-Dihydro-N,n-Dimethyl-2-(1-Piperidinylmethyl)-5H-Dibenz[B,F]Azepine-5-Propan-1-Amine is a high-purity pharmaceutical intermediate and research chemical with a complex tricyclic structure. This compound matters for its role as a key building block in the synthesis of advanced active pharmaceutical ingredients (APIs) and for specialized neuropharmacological research. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in medicinal chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug molecules, particularly in central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and the development of novel pharmacologically active compounds.
• Reference Standard: Used as an analytical standard in quality control (QC) laboratories for method development, validation, and impurity profiling.
• Biochemical Research: Employed in in-vitro studies to investigate interactions with specific biological targets and receptor systems.
• Process Development: Utilized in optimizing synthetic routes and scaling up production for new chemical entities (NCEs).
• Custom Synthesis: Acts as a starting material for the contract manufacturing of specialized, non-commercial compounds for client-specific projects.

Basic Information

Product Name	10,11-Dihydro-N,n-Dimethyl-2-(1-Piperidinylmethyl)-5H-Dibenz[B,F]Azepine-5-Propan-1-Amine
CAS No.	64097-63-8
Molecular Formula	C25H35N3
Molecular Weight	377.57 g/mol
Synonyms	N,N-Dimethyl-3-(10,11-dihydro-2-(piperidin-1-ylmethyl)-5H-dibenzo[b,f]azepin-5-yl)propan-1-amine; 5-[3-(Dimethylamino)propyl]-10,11-dihydro-2-(1-piperidinylmethyl)-5H-dibenzo[b,f]azepine; Desipramine Impurity F; Desmethylclomipramine; Norclomipramine; Clomipramine Metabolite; Norclomipramine Hydrochloride (salt form); 2-[(1-Piperidinyl)methyl]-10,11-dihydro-N,N-dimethyl-5H-dibenzo[b,f]azepine-5-propanamine
EINECS	Contact for details

Quality Control

Our 10,11-Dihydro-N,n-Dimethyl-2-(1-Piperidinylmethyl)-5H-Dibenz[B,F]Azepine-5-Propan-1-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.