Description

5,14-Dihydroxy-3β-[2-(3-Methyl-1-Oxobutoxy)-1-Oxopropoxy]-19-Oxo-5β-Card-20(22)-Enolide is a high-purity, complex cardenolide derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical advanced intermediate or reference standard for the synthesis and study of novel cardiac glycosides and related therapeutic agents. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in developing next-generation cardiovascular treatments or specialized bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthetic pathways for novel cardiotonic agents and cardiac glycosides.
• Reference Standard: High-purity material for analytical method development, validation, and quality control in pharmaceutical manufacturing.
• Biochemical Research: Tool compound for studying the structure-activity relationships (SAR) of cardenolides and their interaction with Na+/K+-ATPase.
• Preclinical Development: Used in the investigation of new chemical entities (NCEs) targeting heart failure and related cardiovascular conditions.
• Fine Chemical Synthesis: Intermediate for the custom synthesis of complex, steroidal natural product derivatives and analogs.

Basic Information

Product Name	5,14-Dihydroxy-3β-[2-(3-Methyl-1-Oxobutoxy)-1-Oxopropoxy]-19-Oxo-5β-Card-20(22)-Enolide
CAS No.	63979-74-8
Molecular Formula	C32H44O9
Molecular Weight	572.69 g/mol
Synonyms	3β-[(2S)-2-(3-Methylbutanoyloxy)propanoyloxy]-5,14-dihydroxy-19-oxo-5β-card-20(22)-enolide; 5,14-Dihydroxy-3β-[2-(3-methyl-1-oxobutoxy)-1-oxopropoxy]-19-oxo-5β,20(22)-cardenolide; 3β-[(2S)-2-(3-Methylbutyryloxy)propionyloxy]-5,14-dihydroxy-19-oxo-5β-card-20(22)-enolide; A derivative of Cardenolide; Cardiac Glycoside Intermediate
EINECS	Contact for details

Quality Control

Our 5,14-Dihydroxy-3β-[2-(3-Methyl-1-Oxobutoxy)-1-Oxopropoxy]-19-Oxo-5β-Card-20(22)-Enolide is produced under a strict quality management system to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods. We support compliance with cGMP guidelines for pharmaceutical intermediates, and specifications can be aligned with client-specific pharmacopeial requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.