Description

α-(Hydroxymethyl)-4-Methylbenzeneacetic Acid 8-Methyl-8-Azabicyclo[3.2.1]Octan-3-Yl Ester is a high-purity synthetic intermediate of significant importance in advanced pharmaceutical research and development. This compound is valued for its complex bicyclic tropane structure, which serves as a critical building block in the synthesis of active pharmaceutical ingredients (APIs). It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of specialized therapeutics, particularly those targeting the central nervous system.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the production of complex active pharmaceutical ingredients (APIs), especially those with tropane alkaloid backbones.
• Neurological Research: Used in the research and development of novel compounds for central nervous system (CNS) disorders.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry: Employed in scale-up and process development for the commercial manufacturing of target drug molecules.
• Reference Standard: Utilized as an analytical reference standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	α-(Hydroxymethyl)-4-Methylbenzeneacetic Acid 8-Methyl-8-Azabicyclo[3.2.1]Octan-3-Yl Ester
CAS No.	63978-26-7
Molecular Formula	C19H27NO3
Molecular Weight	317.42 g/mol
Synonyms	8-Methyl-8-azabicyclo[3.2.1]oct-3-yl α-(hydroxymethyl)-4-methylbenzeneacetate; Tropine 4-methylmandelate ester; 3-Tropanyl α-(hydroxymethyl)-4-methylbenzeneacetate; 8-Methyl-8-azabicyclo[3.2.1]octan-3-yl 2-hydroxy-2-(4-methylphenyl)acetate; NSC 339539; 63978-26-7; Tropane-3α,6β-diol 6-benzoate 3-(4-methylmandelate) (related structure)
EINECS	Contact for details

Quality Control

Our α-(Hydroxymethyl)-4-Methylbenzeneacetic Acid 8-Methyl-8-Azabicyclo[3.2.1]Octan-3-Yl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, open flames, and incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.