Description

Cyclosporin D CAS NO 63775-96-2 is a potent cyclic undecapeptide belonging to the cyclosporin family of immunosuppressive agents. It serves as a critical reference standard and research tool for investigating immunosuppression mechanisms and developing novel therapeutic agents. This high-purity compound is essential for pharmaceutical R&D, academic research, and quality control laboratories focused on immunology and drug discovery.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification, purity assessment, and quantification of related cyclosporins in drug development and quality control.
• Biochemical Research: Employed in studies investigating the mechanism of action of immunosuppressants, particularly their interaction with cyclophilins and calcineurin inhibition.
• Metabolism Studies: Utilized as a probe in pharmacokinetic and metabolic pathway research for cyclosporin analogs.
• Analytical Method Development: Serves as a key analyte for developing and validating HPLC, LC-MS, and other chromatographic methods in analytical laboratories.
• Comparative Bioactivity Assays: Acts as a comparator in in vitro and in vivo assays to evaluate the potency and selectivity of new immunosuppressive compounds.

Basic Information

Product Name	Cyclosporin D
CAS No.	63775-96-2
Molecular Formula	C63H113N11O12
Molecular Weight	1216.63 g/mol
Synonyms	Cyclosporin D; [Thr2,Leu5, D-MeVal11]-Cyclosporin A; [Thr2,Leu5,D-MeVal11]CsA; CsD; Cyclosporine D; (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-[(1R,2R,3S,4R)-3-hydroxy-2-methyl-4-(methylamino)-1-(2-methylpropyl)-6-octenyl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotetratriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
EINECS	Contact for details

Quality Control

Our Cyclosporin D is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for research and reference standard use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all test results against established specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.