Description

Cyclosporin B is a naturally occurring cyclic undecapeptide and a key structural analog of the widely used immunosuppressant Cyclosporin A. This compound is of significant interest in pharmaceutical research and development, particularly for studying structure-activity relationships and exploring novel therapeutic pathways. It serves as a critical reference standard and intermediate for researchers and manufacturers in the life sciences sector, enabling advancements in immunology and drug discovery.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control of related immunosuppressive drugs.
• Biochemical Research: Employed in studies investigating the mechanism of action of cyclophilin inhibitors and calcineurin-mediated signal transduction pathways.
• Drug Discovery Intermediate: Serves as a key starting material or intermediate in the synthesis of novel cyclosporin derivatives with potential therapeutic applications.
• Metabolite Studies: Utilized in pharmacokinetic and metabolic profiling studies of cyclosporin-based therapies.
• Immunology Research: Applied in in vitro and in vivo models to study T-cell activation and immune response modulation.

Basic Information

Product Name	Cyclosporin B
CAS No.	63775-95-1
Molecular Formula	C62H111N11O12
Molecular Weight	1202.61 g/mol
Synonyms	Cyclosporin B; Ciclosporin B; [Thr2,Leu5,D-Val8,Leu10]-Cyclosporin A; OL-27-400; Antibiotic OL 27-400; Cyclosporine B; UNII-5K836YEA1I
EINECS	Contact for details

Quality Control

Our Cyclosporin B is produced and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for research and development use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.