Description

Dihydrocyclosporin D is a chemically modified derivative of the potent immunosuppressive cyclosporine family. This compound is of significant interest in pharmaceutical research and development, particularly for exploring structure-activity relationships and developing novel therapeutic agents. It serves as a critical intermediate and reference standard for scientists in the life sciences sector. Key industries that utilize this specialty chemical include pharmaceutical R&D, biotechnology, and academic research institutions focused on immunology and drug discovery.

Application

• Pharmaceutical Research Intermediate: Used as a key building block in the synthesis and development of novel immunosuppressive or anti-inflammatory drug candidates.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in HPLC, LC-MS, and other analytical techniques.
• Biochemical Research: Employed in studies investigating the mechanism of action of cyclosporine analogs and their interaction with cellular targets like cyclophilins.
• Structure-Activity Relationship (SAR) Studies: Essential for medicinal chemistry programs aimed at modifying the cyclosporine core to enhance potency, reduce toxicity, or alter pharmacokinetic properties.
• Process Chemistry: Utilized in the development and scaling of synthetic routes for complex cyclic peptides and macrocyclic compounds.

Basic Information

Product Name	Dihydrocyclosporin D
CAS No.	63775-91-7
Molecular Formula	C62H111N11O12
Molecular Weight	1202.6 g/mol
Synonyms	Cyclosporin D, Dihydro; [Dihydro]Cyclosporin D; (4R)-4-((E)-2-Butenyl)-4,N-dimethyl-L-threonine-cyclosporin A; UNII-0Q5H5DGG8C; 0Q5H5DGG8C; Dihydro-CsD; Cyclosporine D, dihydro-; Dihydrocyclosporine D
EINECS	Contact for details

Quality Control

Our Dihydrocyclosporin D is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring full traceability and compliance with research-grade specifications. Our commitment is to deliver materials of the highest consistency and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.