Description

Brofaromine is a selective and reversible inhibitor of monoamine oxidase A (MAO-A), belonging to the class of pharmaceutical intermediates and active pharmaceutical ingredients (APIs). This compound is of significant interest for its role in the research and development of novel antidepressant and anxiolytic therapeutics. It is primarily utilized by pharmaceutical manufacturers, biotechnology research firms, and academic institutions engaged in neuropharmacology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of advanced drug candidates targeting monoamine oxidase.
• Neuropharmacology Research: Used as a reference standard and tool compound in preclinical studies investigating MAO-A inhibition and its effects on neurotransmitter levels.
• Active Pharmaceutical Ingredient (API) Development: Serves as the core active moiety in the formulation development of potential antidepressant medications.
• Biochemical Assay Standard: Employed for the calibration and validation of analytical methods (e.g., HPLC, LC-MS) used in pharmacokinetic and metabolic studies.
• Reference Material for Regulatory Submissions: Provides a characterized standard for identity, purity, and potency testing in support of regulatory filings (e.g., IND, NDA).

Basic Information

Product Name	Brofaromine
CAS No.	63638-90-4
Molecular Formula	C₁₇H₁₉BrN₂O₂
Molecular Weight	363.25 g/mol
Synonyms	4-(7-Bromo-5-methoxy-2-benzofuranyl)piperidine; CGP 11,305 A; Ro 11-1163; Brofaronin; (4-(7-Bromo-5-methoxybenzofuran-2-yl)piperidine)
EINECS	Contact for details

Quality Control

Our Brofaromine is manufactured under a quality management system and undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for research and development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We can support development programs requiring material that aligns with ICH guidelines for impurities and stability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.