Description

2,3-Dihydro-2-(N(7)-Guanyl)-3-Hydroxyaflatoxin B1 is a chemically defined, high-purity reference standard critical for analytical and toxicological research. This compound is of significant importance as a key DNA adduct biomarker for studying the carcinogenic mechanism of aflatoxin B1, one of the most potent naturally occurring mycotoxins. It is primarily required by research institutions, analytical laboratories, and pharmaceutical companies engaged in food safety testing, toxicology studies, and biomarker validation.

Application

• Biomarker Research: Serves as a definitive reference standard for the detection and quantification of aflatoxin-DNA adducts in biological samples, crucial for understanding genotoxicity and cancer risk assessment.
• Toxicology Studies: Used in mechanistic studies to elucidate the metabolic activation pathway of Aflatoxin B1 and its subsequent binding to cellular DNA.
• Analytical Method Development: Essential for calibrating advanced analytical instruments like LC-MS/MS and HPLC for highly sensitive and specific assay validation in complex matrices.
• Food and Feed Safety: Supports laboratories in developing and verifying methods to monitor aflatoxin exposure and its biological effects in humans and animals.
• Pharmaceutical R&D: Utilized in drug discovery programs targeting aflatoxin-induced hepatotoxicity or as a tool compound in chemoprevention research.
• Regulatory Compliance: Provides a traceable standard for laboratories requiring compliance with global food safety regulations (e.g., FDA, EFSA) concerning mycotoxin contamination.

Basic Information

Product Name	2,3-Dihydro-2-(N(7)-Guanyl)-3-Hydroxyaflatoxin B1
CAS No.	63425-04-7
Molecular Formula	C24H23N7O8
Molecular Weight	537.48 g/mol
Synonyms	AFB1-Gua; Aflatoxin B1 Guanine Adduct; 2,3-Dihydro-2-(7-guanyl)-3-hydroxyaflatoxin B1; N7-(3-Hydroxy-2,3-dihydro-2-(hydroxymethyl)cyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromen-1-yl)guanine; AFB1-N7-Gua; Guanyl-Aflatoxin B1 Adduct; AFB1-DNA Adduct Standard
EINECS	Contact for details

Quality Control

Every batch of our 2,3-Dihydro-2-(N(7)-Guanyl)-3-Hydroxyaflatoxin B1 is produced and analyzed under strict quality management protocols to ensure identity, purity, and stability. We provide comprehensive analytical data including HPLC purity, spectroscopic confirmation (UV, MS), and chromatographic profile. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming compliance with the specifications for research and analytical use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.