Description

Agomelatine Acetic Acid is a key pharmaceutical intermediate and a derivative of the melatonin receptor agonist agomelatine. This compound is critical for ensuring the quality and efficacy of the final active pharmaceutical ingredient (API) in therapeutic formulations. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of neuropsychiatric medications.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of the antidepressant and chronobiotic drug Agomelatine.
• API Manufacturing: Used in the final stages of Active Pharmaceutical Ingredient (API) production under Good Manufacturing Practices (GMP).
• Research & Development: Serves as a reference standard and starting material in preclinical and clinical research for novel melatoninergic agents.
• Quality Control: Employed as an analytical standard in HPLC and other chromatographic methods to ensure batch purity and consistency.
• Process Chemistry: Utilized in scale-up and optimization studies for robust and cost-effective synthetic routes.

Basic Information

Product Name	Agomelatine Acetic Acid
CAS No.	63319-95-9
Molecular Formula	C17H19NO4
Molecular Weight	301.34 g/mol
Synonyms	N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide Acetic Acid; Agomelatine Related Compound; S 20098 Acetate; S-20098 Acetate; 7-Methoxy-1-naphthaleneacetamide, N-(2-Acetoxyethyl)-; Agomelatine Impurity; Agomelatine Acetate Salt
EINECS	Contact for details

Quality Control

Our Agomelatine Acetic Acid is manufactured and tested to meet stringent pharmaceutical-grade standards. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identification by IR and NMR spectroscopy, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment to ensure full traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.