Description

7,8-Dihydroxy-9,10-Epoxide-7,8,9,10-Tetrahydrobenzo(A)Pyrene-10-Deoxyguanosine is a critical DNA adduct formed from the metabolic activation of benzo[a]pyrene, a well-studied polycyclic aromatic hydrocarbon (PAH). This compound matters as a definitive biomarker for assessing exposure to and metabolic processing of carcinogenic PAHs, providing a direct molecular link to DNA damage. Researchers in toxicology, environmental health, and cancer research need this high-purity reference standard for analytical method development, exposure biomonitoring, and mechanistic studies of chemical carcinogenesis.

Application

• Biomarker Reference Standard: Serves as an analytical standard for the precise quantification of benzo[a]pyrene diol epoxide (BPDE)-DNA adducts in biological samples via techniques like HPLC-MS/MS or 32P-postlabeling.
• Toxicological Research: Used in in vitro and in vivo studies to investigate the mechanisms of PAH-induced mutagenesis, DNA repair, and carcinogenesis.
• Environmental Exposure Assessment: Enables the calibration of assays that monitor human and ecological exposure to combustion-related pollutants, supporting risk assessment studies.
• Cancer Etiology Studies: Facilitates research into the role of specific DNA adducts in the initiation and progression of cancers linked to environmental contaminants.
• Method Validation: Essential for developing, validating, and ensuring the accuracy of sensitive analytical methods in forensic, clinical, and research laboratories.
• Standards for Regulatory Testing: Provides a certified material for laboratories performing compliance testing and safety evaluations related to PAH exposure.

Basic Information

Product Name	7,8-Dihydroxy-9,10-Epoxide-7,8,9,10-Tetrahydrobenzo(A)Pyrene-10-Deoxyguanosine
CAS No.	62698-04-8
Molecular Formula	C30H27N5O6
Molecular Weight	553.57 g/mol
Synonyms	BPDE-N2-dG; (+)-anti-BPDE-N2-dG Adduct; Benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-deoxyguanosine Adduct; 10β-(Deoxyguanosin-N2-yl)-7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene; N2-(10-[7,8,9-Trihydroxy-7,8,9,10-tetrahydrobenzo[a]pyren-10-yl])-2'-deoxyguanosine; BPDE-dG Adduct; PAH-DNA Adduct Standard
EINECS	Contact for details

Quality Control

This high-purity biochemical is manufactured under strict quality control protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Identity and purity are confirmed through a combination of advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, analytical methods, and traceability is provided with each batch to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Off-white to light tan solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥ 95% (Area Percent)
Water Content (KF)	≤ 2.0 %
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.