Description

L-Alanine-2-13C is a stable isotope-labeled analog of the essential amino acid L-Alanine, where the carbon atom at the 2-position is enriched with the non-radioactive isotope Carbon-13. This precise labeling makes it an indispensable tool for advanced metabolic research and analytical method development, providing a reliable internal standard for mass spectrometry and NMR spectroscopy. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for tracer studies, quantitative proteomics, and ensuring the accuracy of complex biochemical analyses.

Application

• Metabolic Pathway Tracer Studies: Used in NMR and Mass Spectrometry to track and quantify metabolic fluxes in cell cultures, tissues, and whole organisms.
• Quantitative Proteomics & Biomarker Discovery: Serves as a critical component in SILAC (Stable Isotope Labeling by Amino acids in Cell culture) and other labeling techniques for accurate protein quantification.
• Pharmaceutical Drug Metabolism & Pharmacokinetics (DMPK): Employed as an internal standard in LC-MS/MS assays to study the absorption, distribution, metabolism, and excretion of new drug candidates with high precision.
• Clinical Diagnostics & Newborn Screening: Used in the development and validation of assays for inborn errors of metabolism, such as maple syrup urine disease.
• Nutritional Research: Facilitates studies on protein synthesis, turnover, and amino acid utilization in nutritional science and sports medicine.
• Biochemical Reagent Manufacturing: Incorporated into high-purity kits and reagents for research and in vitro diagnostic use.

Basic Information

Product Name	L-Alanine-2-13C
CAS No.	62656-85-3
Molecular Formula	C313CH7NO2
Molecular Weight	90.08 g/mol (for 13C labeled form)
Synonyms	(2S)-2-Azaniumyl(2-13C)propanoate; (S)-2-Amino(2-13C)propionic Acid; L-2-Aminopropionic Acid-2-13C; Alanine-2-13C; L-α-Alanine-2-13C; (S)-Alanine-2-13C; 13C Labeled L-Alanine; Stable Isotope Labeled L-Alanine
EINECS	Contact for details

Quality Control

Every batch of L-Alanine-2-13C is manufactured and tested under strict quality management systems. We guarantee high chemical purity and isotopic enrichment, with specifications typically meeting or exceeding the requirements for research and diagnostic applications. Certificates of Analysis (COA) are provided for each lot, detailing key parameters such as assay (HPLC), isotopic purity (NMR/MS), optical rotation, and residual solvent content.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 99 atom % 13C
Optical Rotation	+13.5° to +15.5° (c=1 in H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.