Description

p-Aminophenyl 1-Thio-B-D-Glucuronide is a specialized biochemical reagent, a thioglycoside derivative of glucuronic acid. This compound is valued for its role as a key substrate and synthetic intermediate in enzymatic and chemical research. It is primarily required by pharmaceutical R&D laboratories, diagnostic kit manufacturers, and academic institutions focused on glycosidase and glucuronidase enzyme studies.

Application

• Enzyme Substrate: Critical substrate for the study and assay of β-glucuronidase activity in various biochemical and diagnostic applications.
• Diagnostic Reagent Manufacturing: Used in the production of chromogenic and fluorogenic substrates for clinical diagnostic kits, particularly for detecting bacterial contamination (e.g., E. coli).
• Pharmaceutical Research: Serves as a key intermediate in the synthesis of prodrugs and targeted drug delivery systems designed for enzyme-activated release.
• Bioconjugation Chemistry: Utilized as a linker or hapten in the preparation of immunogens and enzyme conjugates for immunoassay development.
• Microbiology & Cell Biology: Employed in research to visualize and quantify glucuronidase reporter gene expression (GUS assay) in genetic engineering.
• Quality Control (QC) Reference Standard: Acts as a high-purity analytical standard for quality control in the production of related diagnostic and research chemicals.

Basic Information

Item	Detail
Product Name	p-Aminophenyl 1-Thio-B-D-Glucuronide
CAS No.	62205-44-1
Molecular Formula	C12H15NO7S
Molecular Weight	317.31 g/mol
Synonyms	4-Aminophenyl 1-Thio-β-D-Glucopyranosiduronic Acid; 4-Aminophenyl 1-Thio-β-D-Glucuronide; p-Aminophenyl Thioglucuronide; APTG; 1-Thio-β-D-Glucuronide p-Aminophenyl Ester; 62205-44-1; 4-Aminophenyl β-D-Thioglucuronide; p-Aminophenyl β-D-Thioglucuronide
EINECS	Contact for details

Quality Control

Our p-Aminophenyl 1-Thio-B-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the stringent requirements for research and diagnostic applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Solubility	Soluble in water, DMSO; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.