Description

Bredinin 5'-Monophosphate CAS NO 62025-48-3 is a biologically active nucleotide analog and a key intermediate in the synthesis of the immunosuppressive agent Mizoribine. This compound is critical for pharmaceutical research and development, particularly in the study of immunomodulatory pathways and the production of high-purity active pharmaceutical ingredients (APIs). It serves as an essential building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on developing novel therapeutics for autoimmune disorders and organ transplantation.

Application

• Pharmaceutical Intermediate: Primary use as a key synthetic precursor in the commercial production of Mizoribine, an immunosuppressive drug.
• Biochemical Research: Used as a reference standard and tool compound in studies of inosine monophosphate dehydrogenase (IMPDH) inhibition and purine biosynthesis pathways.
• API Development: Serves as a critical starting material for the synthesis and scale-up of high-purity Active Pharmaceutical Ingredients (APIs) for immunosuppressive therapies.
• Process Chemistry: Employed in the development and optimization of scalable, GMP-compliant manufacturing processes for nucleotide-based drugs.
• Academic Research: Utilized in university and institutional labs for investigating the mechanisms of action of immunosuppressive agents and their metabolites.

Basic Information

Product Name	Bredinin 5'-Monophosphate
CAS No.	62025-48-3
Molecular Formula	C9H14N4O9P
Molecular Weight	338.20 g/mol
Synonyms	Mizoribine 5'-Monophosphate; 4-Carbamoyl-1-β-D-ribofuranosylimidazolium-5-olate 5'-Monophosphate; Bredinin Monophosphate; Bredinin 5'-Phosphate; EICAR 5'-Monophosphate (related analog); 5'-O-Phosphonobredinin; (2R,3S,4R,5R)-2-(4-Carbamoyl-5-oxo-4,5-dihydro-1H-imidazol-1-yl)-5-(phosphonooxy)tetrahydrofuran-3,4-diol
EINECS	Contact for details

Quality Control

Our Bredinin 5'-Monophosphate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent specifications for pharmaceutical intermediate applications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support development and commercial projects requiring material produced under GMP guidelines and can supply documentation to meet global regulatory standards (e.g., FDA, ICH).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm
Related Substances (HPLC)	Total impurities < 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.