Description

Thiomuscimol is a sulfur-containing analog of the potent GABAA receptor agonist muscimol, representing a specialized research chemical of significant interest in neuropharmacology. Its unique structure makes it a valuable tool compound for studying receptor subtype specificity and the biochemical role of sulfur in ligand-receptor interactions. This high-purity material is essential for researchers and developers in pharmaceutical R&D, neuroscience, and academic institutions focused on central nervous system drug discovery and neurochemical pathway analysis.

Application

• Neuroscience Research: A critical pharmacological tool for investigating GABAA receptor subtypes, their function, and modulation.
• Drug Discovery & Development: Used as a reference standard and lead compound in the design of novel neuroactive agents targeting inhibitory neurotransmission.
• Biochemical Assays: Employed in in vitro receptor binding studies and functional assays to elucidate structure-activity relationships (SAR).
• Academic & Institutional Research: Supports fundamental studies in neurochemistry, neuropharmacology, and molecular biology of ion channels.
• Metabolic Pathway Analysis: Used to probe the role of GABAergic systems in various physiological and pathological states.
• Analytical Reference Standard: Serves as a high-purity certified material for method development and validation in analytical laboratories.

Basic Information

Product Name	Thiomuscimol
CAS No.	62020-54-6
Molecular Formula	C4H6N2O2S
Molecular Weight	146.17 g/mol
Synonyms	5-Aminomethyl-3-isoxazolol thio analog; 3-Hydroxy-5-(aminomethyl)isothiazole; 5-(Aminomethyl)-3-isothiazolol; 5-(Aminomethyl)isothiazol-3-ol; Muscimol thio analog; GABAA receptor agonist thio-analog
EINECS	Contact for details

Quality Control

Our Thiomuscimol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided, documenting the results of all release tests. We support research integrity with materials produced in compliance with relevant ISO guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.