Description

Emtricitabine is a potent nucleoside reverse transcriptase inhibitor (NRTI) with the CAS number 61548-81-0. It is a critical active pharmaceutical ingredient (API) valued for its high efficacy and favorable safety profile in antiviral therapy. This compound is essential for pharmaceutical manufacturers developing combination therapies for the treatment of HIV-1 infection.

Application

• Antiviral Drug Manufacturing: Primary use as the key API in fixed-dose combination antiretroviral tablets and capsules.
• HIV Treatment Regimens: Formulation into combination drugs such as Truvada® (with tenofovir disoproxil fumarate) and Atripla® (with efavirenz and tenofovir DF).
• Pre-Exposure Prophylaxis (PrEP): Production of medications used for HIV prevention in high-risk populations.
• Pharmaceutical Research & Development: Serving as a reference standard and building block in the discovery of new antiviral agents.
• Generic Drug Production: Sourcing for manufacturers of bioequivalent generic versions of leading antiretroviral therapies.
• Clinical Trial Materials: Supply of GMP-grade material for Phase I-III clinical studies of new HIV treatments and prevention strategies.

Basic Information

Product Name	Emtricitabine
CAS No.	61548-81-0
Molecular Formula	C8H10FN3O3S
Molecular Weight	247.24 g/mol
Synonyms	FTC; Coviracil; (-)-FTC; 5-Fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine; 2',3'-Dideoxy-5-fluoro-3'-thiacytidine; BW 524W91; Emtriva; 4-Amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone
EINECS	Contact for details

Quality Control

Our Emtricitabine is manufactured under strict quality management systems. We offer material compliant with major pharmacopeial standards, including USP and EP monographs. Every batch undergoes rigorous analytical testing for identity, purity, and impurities. A comprehensive Certificate of Analysis (COA) is provided, detailing results for assay, related substances, residual solvents, and microbiological quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity ≤ 0.15%; Total impurities ≤ 0.5%
Water (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Microbiological Enumeration	Complies with EP/USP for non-sterile substances

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.