Description

Lithium Clavulanate is the lithium salt of clavulanic acid, a potent β-lactamase inhibitor. This compound is critical for enhancing the efficacy of β-lactam antibiotics by protecting them from enzymatic degradation. It is primarily utilized by pharmaceutical manufacturers in the production of combination antibiotic therapies for global healthcare markets.

Application

• Pharmaceutical Active Ingredient (API): Key component in fixed-dose combination antibiotics, such as amoxicillin/clavulanate potassium formulations.
• β-Lactamase Inhibition: Used in research and development of new antibiotic formulations to combat bacterial resistance.
• Veterinary Medicine: Incorporated into antibiotic treatments for bacterial infections in animals.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing in laboratories.
• Intermediate Synthesis: Acts as a chemical intermediate in the synthesis of other clavulanate derivatives and related pharmaceutical compounds.

Basic Information

Product Name	Lithium Clavulanate
CAS No.	61177-44-4
Molecular Formula	C8H8LiNO5
Molecular Weight	189.07 g/mol
Synonyms	Clavulanic Acid Lithium Salt; Lithium (2R,3Z,5R)-3-(2-Hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate; Clavulanate Lithium; Lithium Clavulanate Hydrate; (2R,5R,Z)-3-(2-Hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Lithium Salt; BRL 14151 Lithium Salt
EINECS	Contact for details

Quality Control

Our Lithium Clavulanate is manufactured under strict quality systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical applications. A comprehensive Certificate of Analysis (COA) is provided, detailing parameters such as assay, purity, and identification. We support compliance with cGMP and relevant pharmacopeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 95.0% (anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Microbial Enumeration	Meets Ph. Eur. criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.