Description

(S)-(-)-4-Chloromethyl-2,2-Dimethyl-1,3-Dioxolane CAS NO 60456-22-6 is a high-purity chiral building block and key intermediate in organic synthesis. This compound is valued for its role in constructing complex molecules with defined stereochemistry, which is critical for developing active pharmaceutical ingredients (APIs) and advanced materials. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for asymmetric synthesis and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of enantiomerically pure drugs, particularly in antiviral, cardiovascular, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the production of chiral pesticides and herbicides, where the specific stereoisomer can be crucial for biological activity and environmental safety.
• Asymmetric Catalysis: Serves as a precursor for chiral ligands or auxiliaries used in catalytic asymmetric reactions to induce high enantioselectivity.
• Material Science Research: Employed in the development of chiral polymers, liquid crystals, and other functional materials with specific optical properties.
• Process Chemistry & Scale-up: Utilized in route scouting and optimization for the commercial-scale manufacturing of chiral compounds.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry focused on stereocontrolled synthesis and green chemistry principles.

Basic Information

Item	Details
Product Name	(S)-(-)-4-Chloromethyl-2,2-Dimethyl-1,3-Dioxolane
CAS No.	60456-22-6
Molecular Formula	C6H11ClO2
Molecular Weight	150.60 g/mol
Synonyms	(S)-4-(Chloromethyl)-2,2-dimethyl-1,3-dioxolane; (S)-(-)-Solketal Chloride; (S)-1-Chloro-3,3-dimethoxy-2-propanol Cyclic Acetonide; (S)-1-Chloro-2,3-O-isopropylidene-sn-glycerol; (S)-Glycerol Acetonide Chloride; (S)-2,2-Dimethyl-4-chloromethyl-1,3-dioxolane; (S)-Chloromethyl Solketal; (S)-O-Isopropylidene-(R)-Glycerol Chloride
EINECS	Contact for details

Quality Control

Our (S)-(-)-4-Chloromethyl-2,2-Dimethyl-1,3-Dioxolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting standards for research and commercial use. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and enantiomeric excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.