Description

Naja Naja Oxiana Neurotoxin Ii CAS NO 60318-11-8 is a highly purified, short-chain postsynaptic neurotoxin isolated from the venom of the Central Asian cobra. This potent α-neurotoxin is a critical research tool for studying nicotinic acetylcholine receptors (nAChRs) and neuromuscular transmission. It is essential for pharmaceutical R&D, toxicology studies, and the development of novel therapeutics, diagnostics, and antivenoms. Our product is supplied to meet the stringent requirements of advanced life science research.

Application

• Neuroscience Research: A key ligand for the study, mapping, and characterization of muscle-type and neuronal nicotinic acetylcholine receptors.
• Pharmacology & Drug Discovery: Used in high-throughput screening assays to identify and evaluate potential nAChR antagonists, modulators, and novel therapeutic candidates.
• Toxicology & Antivenom Development: Serves as a reference standard for venom analysis, toxicity studies, and the production and quality control of specific antivenoms.
• Biochemical Studies: Employed in structure-activity relationship (SAR) studies to understand toxin-receptor interactions and protein folding.
• Diagnostic Development: Used as a coating antigen or standard in immunoassays (e.g., ELISA) for the detection of snake venom exposure.
• Academic & Institutional Research: A fundamental reagent for university and government labs conducting research on neurobiology, ion channels, and snake venom proteomics.

Basic Information

Product Name	Naja Naja Oxiana Neurotoxin Ii
CAS No.	60318-11-8
Molecular Formula	C~180~H~274~N~52~O~55~S~7
Molecular Weight	~7.8 kDa
Synonyms	Neurotoxin II (Naja naja oxiana); Short-chain Neurotoxin; Cobratoxin; α-Neurotoxin; Postsynaptic Neurotoxin; Naja oxiana Toxin II; NNOVII; Acetylcholine Receptor Antagonist; Snake Venom Toxin
EINECS	Contact for details

Quality Control

Every batch of Naja Naja Oxiana Neurotoxin II is produced and purified under stringent conditions to ensure exceptional consistency and biological activity. Our quality assurance includes rigorous testing for purity, identity, and potency. A comprehensive Certificate of Analysis (COA) detailing assay results, purity by HPLC, and endotoxin levels is provided with each shipment to support your research compliance.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -70°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the vial is at room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to standard
Purity (HPLC)	≥ 95%
Biological Activity (LD~50~)	Contact for details
Protein Content (UV)	≥ 90%
Endotoxin Level (LAL)	< 1.0 EU/µg
Solubility	Soluble in water or saline

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.