Description

3,4-Dihydroxyphenylethylamine-8-14C Hydrochloride-8-14C is a carbon-14 labeled isotopologue of dopamine hydrochloride, a critical neurotransmitter and biochemical precursor. This radiolabeled compound is essential for tracer studies, metabolic pathway analysis, and pharmacokinetic research, providing unparalleled insight into biological processes. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in neuroscience, drug discovery, and biochemical synthesis.

Application

• Biochemical Tracer Studies: Used to trace and quantify the metabolic fate, distribution, and turnover of dopamine and related catecholamines in vivo and in vitro.
• Drug Metabolism and Pharmacokinetics (DMPK): A vital tool for studying the absorption, distribution, metabolism, and excretion (ADME) of dopaminergic drugs and novel therapeutic agents.
• Neuroscience Research: Enables autoradiography and receptor binding assays to investigate dopamine pathways, neurotransmission, and neurological disorders.
• Synthetic Intermediate: Serves as a labeled building block for the synthesis of more complex radiolabeled molecules for research and diagnostic applications.
• Quality Control Reference Standard: Acts as an internal standard in analytical methods like LC-MS for the accurate quantification of dopamine in various matrices.

Basic Information

Product Name	3,4-Dihydroxyphenylethylamine-8-14C Hydrochloride-8-14C
CAS No.	60109-35-5
Molecular Formula	C8H11NO2 • HCl (with 14C at position 8)
Molecular Weight	~189.64 g/mol (unlabeled form)
Synonyms	Dopamine-8-14C Hydrochloride; 4-(2-Aminoethyl)benzene-1,2-diol-8-14C Hydrochloride; 2-(3,4-Dihydroxyphenyl)ethylamine-8-14C Hydrochloride; 3-Hydroxytyramine-8-14C Hydrochloride; DA-8-14C HCl; [8-14C]-Dopamine HCl; Intropin-8-14C Hydrochloride; Revivan-8-14C Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of our carbon-14 labeled compounds is manufactured and analyzed under strict quality systems. We guarantee high radiochemical purity and specific activity, with comprehensive testing including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, radiochemical concentration, and specific activity to support regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a controlled environment to minimize exposure to atmospheric moisture. For long-term storage, consider storage at -20°C under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98% (chemical purity)
Radiochemical Purity	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Solubility	Soluble in water, methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.