Description

8-Oxo-7,8-Dihydrodeoxyguanine is a critical oxidized derivative of deoxyguanosine, widely recognized as a biomarker for oxidative DNA damage. Its significance lies in its role as a standard reference material for quantifying and studying oxidative stress in biological systems, which is fundamental to research in aging, carcinogenesis, and various degenerative diseases. This high-purity compound is essential for researchers and manufacturers in the fields of life science research, diagnostic assay development, and pharmaceutical quality control.

Application

• Biomarker Standard for Oxidative Stress Research: Used as a primary analytical standard to calibrate assays (e.g., HPLC-ECD, LC-MS/MS) measuring 8-oxo-dG levels in DNA, urine, and tissue samples.
• Diagnostic Kit Development: Serves as a key component in the development and validation of commercial ELISA and other immunoassay kits for oxidative damage detection.
• Pharmaceutical & Nutraceutical Testing: Employed in studies to evaluate the efficacy of antioxidants and chemopreventive agents in reducing oxidative DNA damage.
• Toxicology and Environmental Health Studies: Applied in research assessing the genotoxic impact of chemicals, radiation, and environmental pollutants.
• Academic and Clinical Research: A fundamental reagent for investigating the mechanisms of DNA repair pathways and the role of oxidative damage in disease etiology.
• Quality Control for Reference Material Producers: Used as a purity-certified substance by manufacturers of certified reference materials (CRMs) for the life science market.

Basic Information

Product Name	8-Oxo-7,8-Dihydrodeoxyguanine
CAS No.	6957-76-2
Molecular Formula	C10H13N5O5
Molecular Weight	283.24 g/mol
Synonyms	8-Oxo-2'-deoxyguanosine; 8-Oxo-dG; 8-Hydroxy-2'-deoxyguanosine; 8-OHdG; 7,8-Dihydro-8-oxo-2'-deoxyguanosine; 8-Oxo-7,8-dihydro-2'-deoxyguanosine; Oxo8dG; 8-oxoGuo (deoxyribose form)
EINECS	Contact for details

Quality Control

Our 8-Oxo-7,8-Dihydrodeoxyguanine is produced under stringent conditions to ensure the high purity and consistency required for sensitive analytical applications. Each batch undergoes comprehensive analysis, including HPLC purity assay, spectral identification (UV/IR), and verification of moisture content. Certificates of Analysis (COA) detailing all test results are provided to guarantee compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (UV)	Spectrum conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Solubility	Test in specified solvent

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.