Description

S-Acetylmercaptosuccinic Anhydride is a versatile and highly reactive chemical intermediate, primarily valued for its role in the synthesis of thiol-containing compounds and as a key building block in peptide and protein modification. Its core value proposition lies in providing a protected thiol group that can be selectively deacetylated, enabling precise chemical conjugation and functionalization. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require reliable, high-purity intermediates for developing targeted therapeutics, diagnostic agents, and specialized polymers.

Application

• Pharmaceutical Intermediate: Critical for the synthesis of active pharmaceutical ingredients (APIs) and prodrugs that incorporate thiol or disulfide linkages for targeted drug delivery.
• Bioconjugation & Protein Modification: Used to introduce thiol-reactive handles onto peptides, proteins, and antibodies for creating antibody-drug conjugates (ADCs), enzyme inhibitors, and diagnostic probes.
• Polymer Chemistry: Serves as a monomer or cross-linking agent in the production of specialty polymers with tailored properties, such as responsive hydrogels or functional coatings.
• Chemical Synthesis: Acts as a key reagent for introducing protected mercaptosuccinyl groups into complex organic molecules, facilitating further synthetic transformations.
• Research & Development: A valuable tool in academic and industrial R&D labs for exploring new synthetic pathways, developing novel bioconjugation techniques, and creating molecular probes.
• Material Science: Employed in the surface functionalization of nanoparticles and other nanomaterials to enhance biocompatibility or enable specific targeting.

Basic Information

Product Name	S-Acetylmercaptosuccinic Anhydride
CAS No.	6953-60-2
Molecular Formula	C6H6O4S
Molecular Weight	174.18 g/mol
Synonyms	Acetylmercaptosuccinic Anhydride; 3-(Acetylthio)-2,5-furandione; 2,5-Furandione, 3-(acetylthio)-; S-Acetyl-3-mercaptosuccinic Anhydride; 3-(Acetylsulfanyl)-2,5-dihydrofuran-2,5-dione; N-Acetylmercaptosuccinic Anhydride; AMSA; Acetylmercaptosuccinic Acid Anhydride
EINECS	230-126-5

Quality Control

Our S-Acetylmercaptosuccinic Anhydride is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment. We adhere to cGMP principles where applicable to support our customers in pharmaceutical and advanced research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	97 - 102 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.