Description

Citrulin, L-[Ureido-14C] is a radiolabeled derivative of the amino acid L-citrulline, specifically labeled with carbon-14 at the ureido position. This compound is an essential tool for conducting detailed metabolic and pharmacokinetic studies, enabling precise tracking of citrulline and its related pathways in biological systems. It is primarily required by researchers and scientists in the pharmaceutical, biotechnology, and academic sectors for advanced tracer studies, drug metabolism research, and investigations into the nitric oxide cycle.

Application

• Metabolic Tracer Studies: Used to trace the metabolic fate of L-citrulline in urea cycle and nitric oxide synthase pathways.
• Drug Metabolism and Pharmacokinetics (DMPK): Essential for ADME (Absorption, Distribution, Metabolism, Excretion) studies of new pharmaceutical compounds targeting amino acid metabolism.
• Biochemical Research: Employed in in vitro and in vivo experiments to study protein metabolism, amino acid transport, and related enzymatic processes.
• Nitric Oxide (NO) Pathway Analysis: A critical reagent for researching the L-arginine-citrulline-NO cycle in cardiovascular, neurological, and immunological studies.
• Agricultural and Plant Science Research: Can be utilized in studies of nitrogen metabolism in plants.
• Diagnostic Agent Development: Serves as a precursor in the research and development of potential diagnostic imaging agents.

Basic Information

Product Name	Citrulin, L-[Ureido-14C]
CAS No.	6592-96-7
Molecular Formula	C₆H₁₂¹⁴CN₃O₃
Molecular Weight	~177.1 g/mol (for unlabeled form)
Synonyms	L-[Ureido-14C]Citrulline; (S)-2-Amino-5-[carbamoylamino(14C)]pentanoic acid; 14C-L-Citrulline; Carbon-14 labeled L-Citrulline; N5-(Aminocarbonyl)-L-ornithine-ureido-14C; L-Citrulline (ureido-14C); (+)-(S)-2-Amino-5-ureidopentanoic acid-ureido-14C
EINECS	Contact for details

Quality Control

Every batch of Citrulin, L-[Ureido-14C] is manufactured and analyzed under strict quality control protocols to ensure the highest standards of radiochemical purity, chemical purity, and specific activity. Our quality assurance system is designed to meet the rigorous demands of research and regulatory environments. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing parameters such as radionuclidic purity, radiochemical concentration, and analytical method validation.

Storage

Preserve in a tightly closed container, protected from light. Store at recommended temperatures, typically 2-8°C or as specified on the label. The product is light-sensitive and should be handled and stored away from direct light exposure to maintain stability. Keep the container in a well-ventilated area designated for radioactive materials and in compliance with all local and international regulations for handling radiochemicals.

Specification

Item	Specification
Appearance	White to off-white solid or solution (as specified)
Identification (IR/HPLC)	Conforms to reference standard
Assay (Radiochemical Purity)	≥ 97% (by HPLC)
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Chemical Purity (HPLC)	≥ 98%
Solvent (if supplied as solution)	Ethanol/Water or as specified
Radioactivity Concentration	As specified per batch (µCi/mL or mCi/mL)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.