Description

L-Leucine, [14C(U)]- is a stable isotope-labeled analog of the essential amino acid L-Leucine, uniformly labeled with carbon-14. This compound is a critical tool for metabolic and pharmacokinetic studies, enabling precise tracking of leucine pathways in biological systems. It is primarily utilized by researchers and scientists in the pharmaceutical, biotechnology, and life science sectors for advanced tracer studies, drug metabolism research, and biochemical pathway analysis.

Application

• Metabolic Tracer Studies: Used to investigate protein synthesis, turnover, and amino acid metabolism in vivo and in vitro.
• Drug Metabolism and Pharmacokinetics (DMPK): Serves as a radiolabeled tracer to study the absorption, distribution, metabolism, and excretion (ADME) of new chemical entities.
• Biochemical Pathway Analysis: Enables the elucidation of specific metabolic pathways involving leucine, such as the branched-chain amino acid (BCAA) catabolism.
• Nutritional Research: Applied in studies examining muscle protein synthesis, sports nutrition, and metabolic disorders.
• Proteomics and Biomarker Discovery: Facilitates quantitative mass spectrometry-based proteomic analyses for accurate protein quantification.
• Radiochemical Synthesis: Acts as a labeled building block for the synthesis of more complex radiolabeled compounds for research and development.

Basic Information

Product Name	L-Leucine, [14C(U)]-
CAS No.	6109-63-3
Molecular Formula	C6H1314CNO2 *
Molecular Weight	~136.18 (based on 12C) **
Synonyms	(2S)-2-Amino-4-methyl[U-14C]pentanoic acid
L-[U-14C]Leucine
[U-14C]-L-Leucine
Carbon-14 labeled L-Leucine
Uniformly labeled 14C-L-Leucine
Leucine-14C(U)
H-Leu-OH (14C(U))
EINECS	Contact for details

* Formula indicates uniform labeling with Carbon-14. ** Exact molecular weight depends on the specific activity and isotopic enrichment.

Quality Control

Our L-Leucine, [14C(U)]- is manufactured under strict quality systems. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing radiochemical purity, chemical purity, specific activity, and isotopic enrichment. Quality assurance includes rigorous analytical testing via HPLC and radio-HPLC to ensure compliance with the stringent requirements for research-grade radiolabeled compounds. Certificates are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Handle and store in accordance with all applicable radiation safety regulations and guidelines.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98% (chemical purity)
Radiochemical Purity (Radio-HPLC)	≥ 97%
Specific Activity	Customizable (Contact for details)
Solubility	Soluble in water, dilute acid, and alkali

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.