Description

Scopolamine Methyl Nitrate is a quaternary ammonium salt derivative of the tropane alkaloid scopolamine. This compound is valued for its potent anticholinergic properties and enhanced stability in formulation compared to its parent base. It serves as a critical active pharmaceutical ingredient (API) and a key intermediate in the synthesis of specialized pharmaceuticals, primarily targeting the central and peripheral nervous systems. Global B2B buyers in the pharmaceutical and fine chemical sectors rely on this material for its consistent quality and reliable performance in advanced manufacturing processes.

Application

• Pharmaceutical API: Primary use as the active ingredient in formulations for motion sickness prevention and treatment.
• Transdermal Therapeutic Systems: Key component in patches designed for controlled, long-term delivery of anticholinergic medication.
• Preoperative Medication: Used in formulations to reduce salivary and bronchial secretions before surgery.
• Ophthalmic Solutions: Employed in diagnostic procedures to induce cycloplegia (paralysis of the ciliary muscle) and mydriasis (pupil dilation).
• Gastrointestinal Antispasmodics: Incorporated into medications for relieving cramps and spasms of the stomach, intestines, and bladder.
• Chemical Intermediate: Serves as a crucial precursor in the synthesis of other high-value, specialized tropane alkaloid derivatives.
• Research & Development: Utilized in biochemical and pharmacological research to study muscarinic acetylcholine receptor antagonists.

Basic Information

Product Name	Scopolamine Methyl Nitrate
CAS No.	6106-46-3
Molecular Formula	C18H24N2O4
Molecular Weight	332.40 g/mol
Synonyms	Hyoscine Methyl Nitrate; Scopolamine Methonitrate; Methscopolamine Nitrate; Pamine Nitrate; (1R,2R,4S,5S,7s)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.0²,⁴]non-7-yl (2S)-3-hydroxy-2-phenylpropanoate methyl nitrate; N-Methylscopolamine Nitrate; Scopolamine N-Methyl Nitrate; Tropane-3α-ol, 6β,7β-epoxy-1αH,5αH-, (-)-, methyl nitrate, ester with (-)-(S)-tropic acid
EINECS	Contact for details

Quality Control

Our Scopolamine Methyl Nitrate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with pharmaceutical-grade standards. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters such as assay, related substances, residual solvents, and microbiological quality. We support compliance with major pharmacopoeial standards (USP/EP) and regulatory frameworks including GMP, ICH Q7, and REACH.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent absorption of atmospheric moisture, which can affect stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm
Microbiological Enumeration	Meets Ph. Eur. 2.6.12 / USP <61>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.