Description

Eserine Hydrochloride is a high-purity pharmaceutical-grade alkaloid salt, a critical intermediate in ophthalmic and neurological research. Its primary value lies in its potent acetylcholinesterase inhibitory activity, making it essential for modulating cholinergic signaling pathways. This compound is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of diagnostic reagents and reference standards for glaucoma and myasthenia gravis studies.

Application

• Pharmaceutical Intermediate: Key starting material or active ingredient in the synthesis of ophthalmic solutions for glaucoma treatment.
• Biochemical Research: Used as a standard acetylcholinesterase inhibitor in enzymatic assays and neurological studies.
• Reference Standard: Serves as a certified reference material (CRM) for quality control in pharmaceutical manufacturing and analytical method validation.
• Diagnostic Reagents: Component in in vitro diagnostic kits for studying cholinergic function and related disorders.
• Academic & Clinical Research: Investigated for its potential effects on cognitive function, smooth muscle contraction, and intraocular pressure.

Basic Information

Product Name	Eserine Hydrochloride
CAS No.	6091-12-9
Molecular Formula	C15H22ClN3O2
Molecular Weight	311.81 g/mol
Synonyms	Physostigmine Hydrochloride; Eserine Chloride; Physostigminium Chloride; (3aR,8aS)-1,3a,8-Trimethyl-1H,2H,3H,3aH,8H,8aH-pyrrolo[2,3-b]indol-5-yl N-methylcarbamate hydrochloride; Physostol; Antilirium (brand name reference); Isopto-Eserine (brand name reference)
EINECS	228-045-6

Quality Control

Our Eserine Hydrochloride is manufactured under strict quality management systems, with purity typically meeting or exceeding 98.0% (by HPLC). Each batch is tested for identity, potency, and specific impurities to ensure compliance with internal specifications suitable for research and pharmaceutical intermediate use. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption and decomposition. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.