Description

Physostigmine Methiodide is a quaternary ammonium salt derivative of the alkaloid physostigmine, primarily recognized for its potent acetylcholinesterase inhibitory activity. This compound is critical for research and development in neuropharmacology, serving as a key reference standard and a precursor in the synthesis of more complex cholinergic agents. It is essential for pharmaceutical R&D laboratories, academic institutions, and chemical manufacturers focused on developing treatments for neurological disorders and studying cholinergic signaling pathways.

Application

• Pharmaceutical Reference Standard: Used as a high-purity analytical standard for quality control and method validation in drug development.
• Neuropharmacology Research: A vital tool for in vitro and ex vivo studies investigating acetylcholinesterase inhibition and cholinergic neurotransmission.
• Chemical Synthesis Intermediate: Serves as a key building block for synthesizing novel analogs and derivatives with potential therapeutic applications.
• Biochemical Assay Reagent: Employed in enzymatic assays to study kinetics and mechanisms of cholinesterase activity.
• Academic & Educational Use: Utilized in university laboratories for teaching advanced principles of medicinal chemistry and neurobiology.

Basic Information

Product Name	Physostigmine Methiodide
CAS No.	6091-11-8
Molecular Formula	C16H22IN3O2
Molecular Weight	415.27 g/mol
Synonyms	Eserine Methiodide; Physostigmine, methiodide; Eseroline, N-methyl-, methiodide; 1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-ol methylcarbamate (ester), methiodide; (3aS-cis)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-yl methylcarbamate methiodide; N-Methylphysostigmine Iodide; MI-217
EINECS	Contact for details

Quality Control

Our Physostigmine Methiodide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.