Description

Acetyl Chloride, [1-14C] is a carbon-14 labeled derivative of acetyl chloride, a fundamental reagent for introducing the acetyl group. This radiolabeled compound is essential for precise metabolic and pharmacokinetic studies, enabling researchers to track the fate of acetyl moieties in complex biological and chemical systems. It is a critical tool for scientists in pharmaceutical R&D, agrochemical development, and advanced organic synthesis, particularly for autoradiography and tracer experiments.

Application

• Tracer Studies in Drug Metabolism and Pharmacokinetics (DMPK): Used to label drug candidates for tracking absorption, distribution, metabolism, and excretion (ADME) pathways.
• Mechanistic Biochemical Research: Employed in enzymatic studies to investigate acetylation reactions and metabolic pathways.
• Agrochemical Research: Utilized to study the environmental fate and metabolic degradation of pesticides and herbicides.
• Organic Synthesis of Labeled Compounds: Serves as a key radiolabeled building block for the synthesis of more complex carbon-14 labeled intermediates and final target molecules.
• Autoradiography: Provides the radioactive source for imaging techniques to visualize the location of labeled compounds in tissues or on chromatograms.

Basic Information

Product Name	Acetyl Chloride, [1-14C]
CAS No.	676-77-7
Molecular Formula	C14CH3COCl / C2H3ClO (*14C labeled)
Molecular Weight	~78.50 g/mol (for 14C labeled form)
Synonyms	Acetic-1-14C acid chloride; [1-14C]Acetyl chloride; [Carbonyl-14C]acetyl chloride; Ethanoyl-1-14C chloride; Radioactive Acetyl Chloride; 14C-Acetyl Chloride; RCIA; Radiolabeled Acetyl Chloride
EINECS	211-634-5 (for unlabeled form)

Quality Control

Every batch of Acetyl Chloride, [1-14C] is manufactured and analyzed under strict quality systems to ensure high chemical and radiochemical purity, specific activity, and stability. Our quality commitment includes adherence to cGMP principles for radiopharmaceutical precursors. A comprehensive Certificate of Analysis (COA) detailing purity, specific activity, solvent, and analytical methods (HPLC, GC, etc.) is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Due to its nature as a highly volatile and moisture-sensitive strong acid/organic solvent, store in a cool, dry, and well-ventilated area. For optimal stability, we recommend storage at or below -20°C. All handling must comply with local and international regulations for radioactive materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR/NMR)	Conforms to structure
Chemical Purity (GC/HPLC)	≥ 98%
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	Contact for details (mCi/mmol)
Solvent	Benzene, Toluene, or as specified
Concentration	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.