Description

3-Fluorophthalic Anhydride is a high-value fluorinated aromatic building block essential for advanced organic synthesis. Its unique structure, featuring both a reactive anhydride and a fluorine substituent, makes it a critical intermediate for creating complex molecules with tailored properties. This compound is primarily sought after by R&D and production teams in the pharmaceutical, agrochemical, and specialty polymer industries for developing novel active ingredients and high-performance materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs), including potential kinase inhibitors and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the fluorine atom enhances biological activity and environmental stability.
• Polymer & Material Science: Serves as a monomer or modifier for engineering plastics, polyimides, and epoxy resins to improve thermal stability, chemical resistance, and dielectric properties.
• Liquid Crystal & OLED Materials: A precursor for fluorinated components in electronic display materials, contributing to improved performance and longevity.
• Dye & Pigment Intermediate: Employed in the synthesis of specialized fluorinated dyes and pigments for high-value applications.
• Cross-coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Suzuki, Heck) to create complex biaryl structures for drug discovery.

Basic Information

Product Name	3-Fluorophthalic Anhydride
CAS No.	652-39-1
Molecular Formula	C8H3FO3
Molecular Weight	166.11 g/mol
Synonyms	3-Fluorophthalic Acid Anhydride; 3-Fluoroisobenzofuran-1,3-dione; 1,3-Dioxo-1,3-dihydroisobenzofuran-5-fluoride; 5-Fluorophthalic Anhydride; 4-Fluorophthalic Anhydride (common misnomer); 3-FPA; 3-Fluorobenzene-1,2-dicarboxylic Anhydride
EINECS	211-477-0

Quality Control

Every batch of our 3-Fluorophthalic Anhydride is manufactured and tested under a strict quality management system. We provide comprehensive analytical documentation to ensure traceability and compliance with your project requirements. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under dry conditions to prevent hydrolysis and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	105 - 110 °C
Loss on Drying	≤0.5%
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.