Description

2,3,5,6-Tetrafluoro-4-Hydroxy-Benzoic Acid is a highly fluorinated benzoic acid derivative, serving as a critical building block in advanced organic synthesis. Its unique perfluorinated aromatic core with a phenolic hydroxyl group makes it a versatile intermediate for introducing fluorine atoms into target molecules, which is essential for modifying physical, chemical, and biological properties. This compound is particularly valuable for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients with enhanced metabolic stability, bioavailability, and lipophilicity.

Application

• Pharmaceutical Intermediate: Key synthon for the development of fluorinated drug candidates, including protease inhibitors, kinase inhibitors, and antibacterial agents.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where fluorine substitution improves efficacy and environmental profile.
• Liquid Crystal Materials: Serves as a precursor for fluorinated mesogens in high-performance liquid crystal displays (LCDs).
• Polymer Modification: Incorporated into specialty polymers to enhance chemical resistance, thermal stability, and surface properties.
• Organic Electronics: Building block for electron-transport materials and semiconductors in OLEDs and organic photovoltaics.
• Complex Ligand Synthesis: Used to prepare fluorinated ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	2,3,5,6-Tetrafluoro-4-Hydroxy-Benzoic Acid
CAS No.	652-34-6
Molecular Formula	C7H2F4O3
Molecular Weight	210.09 g/mol
Synonyms	2,3,5,6-Tetrafluoro-4-hydroxybenzoic acid; 4-Hydroxy-2,3,5,6-tetrafluorobenzoic acid; Tetrafluorohydroxybenzoic acid; Perfluoro-4-hydroxybenzoic acid; Benzoic acid, 2,3,5,6-tetrafluoro-4-hydroxy-; 2,3,5,6-Tetrafluoro-4-hydroxybenzoic acid; 652-34-6 (CAS); TFB-OH
EINECS	211-476-6

Quality Control

Our 2,3,5,6-Tetrafluoro-4-Hydroxy-Benzoic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic nature, the container should be kept sealed under dry, inert conditions to prevent moisture absorption. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	210°C - 215°C
Loss on Drying	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.