Description

2,3,4,5,6-Pentafluorobenzamide is a high-purity fluorinated aromatic building block characterized by its unique pentafluorophenyl group attached to a primary amide functionality. This compound is a critical intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its fluorine atoms impart enhanced stability, lipophilicity, and metabolic resistance. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing novel compounds with targeted properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, including kinase inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in creating advanced herbicides and pesticides where the fluorine atoms improve biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, enhancing thermal stability and optical properties.
• Polymer Modification: Incorporated as a monomer or additive to produce specialty polymers with improved chemical resistance and surface characteristics.
• Analytical Chemistry: Employed as a derivatization agent or a standard in chromatographic methods (HPLC, GC) for detection and quantification.
• Organic Synthesis & Catalysis: Acts as a versatile building block in cross-coupling reactions and as a ligand precursor in organometallic catalysis.

Basic Information

Product Name	2,3,4,5,6-Pentafluorobenzamide
CAS No.	652-31-3
Molecular Formula	C7H2F5NO
Molecular Weight	211.09 g/mol
Synonyms	Pentafluorobenzamide; 2,3,4,5,6-Pentafluorobenzoic acid amide; Benzamide, 2,3,4,5,6-pentafluoro-; Perfluorobenzamide; NSC 403697; Amide of Pentafluorobenzoic Acid; PFBA
EINECS	211-477-5

Quality Control

Our 2,3,4,5,6-Pentafluorobenzamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements of our global clientele. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with relevant industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	168 - 172 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.