Description

(Pentafluorophenyl)Glycolic Acid is a high-value fluorinated aromatic building block characterized by its reactive carboxylic acid and hydroxyl groups attached to a perfluorinated phenyl ring. This unique structure makes it a critical intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs) where enhanced stability, lipophilicity, and electronic properties are required. It is essential for R&D and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate pentafluorophenyl motifs into their molecular designs.

Application

The compound serves as a versatile synthon in organic synthesis, primarily due to the electron-deficient nature of the pentafluorophenyl group which activates adjacent functional groups. Key application areas include:

• Pharmaceutical Intermediates: Synthesis of novel drug candidates, particularly in medicinal chemistry for creating protease inhibitors, kinase inhibitors, and other targeted therapies.
• Agrochemical Synthesis: Building block for advanced herbicides, fungicides, and insecticides that benefit from the stability and bioactivity of fluorine-containing aromatics.
• Ligand and Catalyst Development: Precursor for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science: Monomer or modifier for high-performance polymers, liquid crystals, and organic electronic materials.
• Bioconjugation and Probe Synthesis: Used in developing fluorescent probes, affinity labels, and other biochemical tools where the pentafluorophenyl group acts as a reactive handle.
• Custom Synthesis and Contract Manufacturing: A key starting material for custom chemical synthesis services catering to advanced R&D projects.

Basic Information

Product Name	(Pentafluorophenyl)Glycolic Acid
CAS No.	652-24-4
Molecular Formula	C8H3F5O3
Molecular Weight	242.10 g/mol
Synonyms	2-Hydroxy-2-(pentafluorophenyl)acetic acid; α-Hydroxy-pentafluorophenylacetic acid; Pentafluoromandelic acid; 2-(Perfluorophenyl)-2-hydroxyacetic acid; (Perfluorophenyl)glycolic acid; PFP-glycolic acid; 652-24-4; NSC 163082
EINECS	211-477-6

Quality Control

We maintain a rigorous quality management system to ensure batch-to-batch consistency and high purity. Our (Pentafluorophenyl)Glycolic Acid is produced and tested under controlled conditions, with specifications verified by advanced analytical techniques including HPLC, NMR, and FT-IR. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability. The material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.