Description

2,3,5,6-Tetrafluorobenzoic Acid is a highly fluorinated aromatic carboxylic acid, serving as a critical building block in advanced organic synthesis. Its value lies in the unique electronic and steric properties imparted by the tetrafluoro substitution pattern, which is instrumental in modifying the reactivity and stability of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of active pharmaceutical ingredients (APIs), especially those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and pesticides, where the fluorine atoms improve lipophilicity and biological activity.
• Liquid Crystal Materials: Serves as a precursor for fluorinated liquid crystal compounds used in display technologies.
• Polymer Modification: Incorporated as a monomer or additive to create specialty polymers with improved chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, esterifications, and amide bond formations to introduce a perfluorinated benzoic acid moiety.
• Coordination Chemistry & Ligand Design: Acts as a ligand or precursor for metal-organic frameworks (MOFs) and catalysts.

Basic Information

Product Name	2,3,5,6-Tetrafluorobenzoic Acid
CAS No.	652-18-6
Molecular Formula	C7H2F4O2
Molecular Weight	194.08 g/mol
Synonyms	Benzoic acid, 2,3,5,6-tetrafluoro-; Perfluoroisophthalic acid (common misnomer); Tetrafluorobenzoic acid; 2,3,5,6-TFBA; NSC 92356; 2,3,5,6-Tetrafluorobenzenecarboxylic acid; α,α,α,α-Tetrafluoroisophthalic acid (deprecated); TFBzA
EINECS	211-477-6

Quality Control

Our 2,3,5,6-Tetrafluorobenzoic Acid is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by FT-IR and NMR, to ensure it meets exacting standards for research and industrial use. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	155 - 160 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.