Description

Uracil, [2-14C] is a carbon-14 radiolabeled analog of the fundamental pyrimidine nucleobase uracil, specifically labeled at the 2-position. This compound is an essential tool for tracing metabolic pathways, studying nucleic acid synthesis, and investigating the pharmacokinetics of related pharmaceuticals. It is primarily utilized by research scientists and quality control laboratories in the pharmaceutical, biotechnology, and agrochemical industries for advanced tracer studies and ADME (Absorption, Distribution, Metabolism, and Excretion) research.

Application

• Metabolic Pathway Tracing: Used as a radiolabeled tracer to study the biosynthesis and catabolism of pyrimidines in biological systems.
• Nucleic Acid Research: Employed in investigations of RNA synthesis, repair mechanisms, and nucleotide pool dynamics.
• Drug Metabolism Studies (ADME): Critical for labeling drug candidates that are uracil analogs to track their absorption, distribution, metabolism, and excretion in preclinical research.
• Biochemical Assay Development: Serves as a standard or substrate in enzymatic assays for kinases, phosphorylases, and other nucleotide-metabolizing enzymes.
• Agricultural Chemical Research: Applied in studies to understand the mode of action and environmental fate of uracil-based herbicides or plant growth regulators.
• Quality Control & Reference Standard: Used as an internal standard in analytical methods such as LC-MS for quantifying uracil and its derivatives in complex matrices.

Basic Information

Product Name	Uracil, [2-14C]
CAS No.	626-07-3
Molecular Formula	C4H414CN2O2
Molecular Weight	~114.1 g/mol (exact mass depends on specific activity)
Synonyms	2,4(1H,3H)-Pyrimidinedione, [2-14C]; [2-14C]Uracil; 2-14C-Uracil; Uracil-2-14C; NSC 2100; 2-Hydroxy-4-pyrimidinone, [2-14C]; 2,4-Dihydroxypyrimidine, [2-14C]; 2,4-Pyrimidinediol, [2-14C]
EINECS	210-916-3

Quality Control

Every batch of Uracil, [2-14C] is manufactured and analyzed under strict quality systems to ensure radiochemical purity, specific activity, and chemical identity. Comprehensive testing includes HPLC, TLC, and spectroscopic analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting the exact specifications, including radionuclidic purity and analytical chromatograms. Our quality commitment aligns with the needs of GLP (Good Laboratory Practice) and cGMP (current Good Manufacturing Practice) environments.

Storage

Preserve in a tightly closed container, protected from light. Store at recommended temperatures, typically 2-8°C or as specified on the label. This product is light-sensitive (store away from light). Handle and store in accordance with all applicable radiation safety regulations and guidelines.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98% (chemical purity)
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Solvent (if supplied as solution)	Specified on COA (e.g., Ethanol/Water)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.