Description

Colchicine is a potent alkaloid compound of significant pharmaceutical importance, primarily known for its anti-inflammatory and anti-gout properties. Its core value lies in its ability to bind to tubulin, inhibiting microtubule polymerization, which makes it a critical agent in both therapeutic and research contexts. This product is essential for pharmaceutical manufacturers, research institutions, and laboratories involved in developing treatments for gout, familial Mediterranean fever, and as a tool compound in cell biology studies.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the formulation of prescription medications for acute gout flares and prophylaxis.
• Research & Development: Utilized as a biochemical tool to study microtubule dynamics, cell division (mitosis), and inflammation pathways in vitro.
• Anti-inflammatory Therapeutics: Investigated for potential applications in treating pericarditis and other inflammatory conditions.
• Botanical Reference Standard: Serves as a high-purity standard for the quality control of plant extracts, particularly from the Colchicum autumnale plant.

Basic Information

Product Name	Colchicine
CAS No.	64-86-8
Molecular Formula	C22H25NO6
Molecular Weight	399.44 g/mol
Synonyms	Colchicine; Colchicin; Colchicina; Colchiceine Trimethyl Ether; (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide; NSC 757; Colsalide; Colgout
EINECS	200-598-5

Quality Control

Our Colchicine is manufactured and tested under strict quality management systems to ensure it meets the rigorous standards required for pharmaceutical and research use. We offer grades compliant with major pharmacopoeial standards, including USP and EP. A comprehensive Certificate of Analysis (COA), detailing purity, identity, and impurity profiles, is provided with each batch to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Specific Optical Rotation	-240° to -250° (c=1 in CHCl3)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.